氯氮卓和吗啡可降低清醒大鼠对脑刺激的升压反应。
Chlordiazepoxide and morphine reduce pressor response to brain stimulation in awake rats.
作者信息
Brandão M L, Vasquez E C, Cabral A M, Schmitt P
出版信息
Pharmacol Biochem Behav. 1985 Dec;23(6):1069-71. doi: 10.1016/0091-3057(85)90116-9.
The effects of intravenous as well as dorsal midbrain injections of morphine and chlordiazepoxide on the blood pressure rise induced by electrical stimulation of the dorsal periaqueductal gray matter (DPAG) were studied in unanesthetized rats. Chlordiazepoxide applied systemically or locally into the DPAG, as well as locally applied but not systemically injected morphine were found to attenuate the centrally-induced hypertension. These data together with others suggest that benzodiazepines as well as local injections of morphine into the DPAG decrease the aversive effect induced by DPAG stimulation.
在未麻醉的大鼠中，研究了静脉注射以及中脑背侧注射吗啡和氯氮卓对电刺激导水管周围灰质背侧（DPAG）引起的血压升高的影响。发现全身应用或局部应用于DPAG的氯氮卓，以及局部应用但未全身注射的吗啡，均可减轻中枢性高血压。这些数据以及其他数据表明，苯二氮卓类药物以及向DPAG局部注射吗啡可降低DPAG刺激引起的厌恶效应。
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