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丘脑 PLCβ4 缺失破坏非快速动眼睡眠的不稳定性，损害睡眠依赖的记忆巩固。

Destabilization of light NREM sleep by thalamic PLCβ4 deletion impairs sleep-dependent memory consolidation.

机构信息

Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, 03722, Republic of Korea.

School of Life Science, Ulsan National Institute of Science and Technology, Ulsan, 44919, Republic of Korea.

出版信息

Sci Rep. 2020 Jun 1;10(1):8813. doi: 10.1038/s41598-020-64377-7.

DOI:10.1038/s41598-020-64377-7
PMID:32483199
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7264240/
Abstract

Sleep abnormality often accompanies the impairment of cognitive function. Both rapid eye movement (REM) and non-REM (NREM) sleep have associated with improved memory performance. However, the role of composition in NREM sleep, consisting of light and deep NREM, for memory formation is not fully understood. We investigated how the dynamics of NREM sleep states influence memory consolidation. Thalamocortical (TC) neuron-specific phospholipase C β4 (PLCβ4) knockout (KO) increased the total duration of NREM sleep, consisting of destabilized light NREM and stabilized deep NREM. Surprisingly, the longer NREM sleep did not improve memory consolidation but rather impaired it in TC-specific PLCβ4 KO mice. Memory function was positively correlated with the stability of light NREM and spindle activity occurring in maintained light NREM period. Our study suggests that a single molecule, PLCβ4, in TC neurons is critical for tuning the NREM sleep states and thus affects sleep-dependent memory formation.

摘要

睡眠异常常伴随着认知功能的损害。快速眼动 (REM) 和非快速眼动 (NREM) 睡眠都与改善记忆表现有关。然而，对于由浅 NREM 和深 NREM 组成的 NREM 睡眠的组成部分在记忆形成中的作用还不完全清楚。我们研究了 NREM 睡眠状态的动态如何影响记忆巩固。丘脑皮质 (TC) 神经元特异性磷酯酶 Cβ4 (PLCβ4) 敲除 (KO) 增加了 NREM 睡眠的总持续时间，包括不稳定的浅 NREM 和稳定的深 NREM。令人惊讶的是，较长的 NREM 睡眠并没有改善记忆巩固，反而损害了 TC 特异性 PLCβ4 KO 小鼠的记忆巩固。记忆功能与轻 NREM 的稳定性以及在维持的轻 NREM 期间发生的纺锤波活动呈正相关。我们的研究表明，TC 神经元中的单个分子 PLCβ4 对于调节 NREM 睡眠状态至关重要，从而影响睡眠依赖性记忆形成。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c40/7264240/e0d9d67cee9d/41598_2020_64377_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c40/7264240/72d4a69f68d6/41598_2020_64377_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c40/7264240/8db6b0778b1b/41598_2020_64377_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c40/7264240/9b1ac9af1e35/41598_2020_64377_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c40/7264240/a8045c7a9cd5/41598_2020_64377_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c40/7264240/d6b2927efce3/41598_2020_64377_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c40/7264240/e0d9d67cee9d/41598_2020_64377_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c40/7264240/72d4a69f68d6/41598_2020_64377_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c40/7264240/8db6b0778b1b/41598_2020_64377_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c40/7264240/9b1ac9af1e35/41598_2020_64377_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c40/7264240/a8045c7a9cd5/41598_2020_64377_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c40/7264240/d6b2927efce3/41598_2020_64377_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c40/7264240/e0d9d67cee9d/41598_2020_64377_Fig6_HTML.jpg

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