哺乳动物组织中的磷酸吡哆胺（吡哆醇）氧化酶活性。
Pyridoxamine (pyridoxine) phosphate oxidase activity in mammalian tissues.
作者信息
Fonda M L
机构信息
Department of Biochemistry, University of Louisville School of Medicine, Health Sciences Center, KY 40292.
出版信息
Comp Biochem Physiol B. 1988;90(4):731-7. doi: 10.1016/0305-0491(88)90327-6.
PMID:3248367
Abstract
- Vitamin B6-sufficient rats had moderate pyridoxamine-P oxidase specific activities in heart, brain, kidney and liver, but no detectable activity in skeletal muscle. Vitamin B6-deficiency in rats resulted in a decreased oxidase activity in liver but no change in the activities in other tissues. 2. The pyridoxamine-P oxidase activity in vitamin B6-sufficient mice was high in liver, moderate in brain and kidney, and not measurable in skeletal muscle and heart. Vitamin B6-deficient, compared with control mice, had decreased oxidase activities in brain, kidney and liver. 3. Mouse erythrocytes took up pyridoxine more rapidly than did rat and human erythrocytes. 4. Mouse and human erythrocytes rapidly converted pyridoxine to pyridoxal-P. Rat, hamster and rabbit erythrocytes had appreciably lower pyridoxamine-P oxidase activity than did mouse and human erythrocytes.
摘要
- 维生素B6充足的大鼠在心脏、大脑、肾脏和肝脏中具有适度的吡哆胺 - P氧化酶比活性，但在骨骼肌中未检测到活性。大鼠维生素B6缺乏导致肝脏中氧化酶活性降低，但其他组织中的活性没有变化。2. 维生素B6充足的小鼠肝脏中的吡哆胺 - P氧化酶活性高，大脑和肾脏中的活性中等，在骨骼肌和心脏中无法测量。与对照小鼠相比，维生素B6缺乏的小鼠大脑、肾脏和肝脏中的氧化酶活性降低。3. 小鼠红细胞摄取吡哆醇的速度比大鼠和人类红细胞快。4. 小鼠和人类红细胞能迅速将吡哆醇转化为磷酸吡哆醛。大鼠、仓鼠和兔子红细胞的吡哆胺 - P氧化酶活性明显低于小鼠和人类红细胞。
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