Faculty of Chemistry, Warsaw University of Technology, Noakowskiego 3, Warsaw, 00-664, Poland.
Faculty of Chemical and Process Engineering, Warsaw University of Technology, Waryńskiego 1, Warsaw, 00-645, Poland.
Macromol Biosci. 2020 Jul;20(7):e2000063. doi: 10.1002/mabi.202000063. Epub 2020 Jun 2.
The antimicrobial properties of polycations are strongly affected by the structural features such as the backbone flexibility and topology (isomerism) through the polymer ability to attain proper conformation in interaction with the cell membrane. In this paper, a synthesis and biocidal properties evaluation of ionenes characterized by different backbone topology (isomerism) and flexibility are presented. The findings reveal influence of variation in topology on activity against different microorganisms, and general positive effect of improved flexibility. Furthermore, one of the obtained ionenes displays degradable properties in near physiological environment (phosphate-buffered saline pH 7.4, 37 °C). The degradation proceeds via Hofmann elimination reaction and the products are not of acidic character. For the first time a new class of degradable ionenes with a high antimicrobial potential is presented.
聚阳离子的抗菌性能强烈受到结构特征的影响，如主链的柔韧性和拓扑结构（异构性），这是通过聚合物在与细胞膜相互作用时能够获得适当构象的能力。本文介绍了具有不同主链拓扑结构（异构性）和柔韧性的离聚物的合成和杀菌性能评价。研究结果表明，拓扑结构的变化对不同微生物的活性有影响，并且柔韧性的提高通常有积极的影响。此外，所得到的离聚物之一在近生理环境（磷酸盐缓冲盐水 pH7.4，37°C）中显示出可降解的性质。降解通过霍夫曼消除反应进行，产物没有酸性。首次提出了一类具有高抗菌潜力的新型可降解离聚物。
