Laboratorio de Tecnologia dos Medicamentos, Federal University of Pernambuco (UFPE), Recife-PE, Brazil.
Central de Analise de Farmacos, Medicamentos e Alimentos, Federal University of Vale do Sao Francisco (UNIVASF), Petrolina-PE, Brazil.
Curr Med Chem. 2021;28(10):2062-2076. doi: 10.2174/0929867327666200525160556.
Inflammation is an essential response provided by the immune system, ensuring the survival during microbial infection, tissue injury and other noxious conditions. However, prolonged inflammatory processes are often associated with severe side effects on health.
This systematic review aimed to provide the evidence in the literature of the preclinical and human anti-inflammatory activity of gallium compounds from 2000 to 2019 focused on elucidating the mechanisms involved in the inflammatory process.
Seven bibliographical databases were consulted (PubMed, Medline, ScienceDirect, Scopus, Springer, Web of Science, and EBSCOhost). The selection of appropriate publications and writing of this systematic review were based on the guidelines mentioned in the PRISMA statement. Moreover, the assessment of the methodological quality of the selected studies was also performed.
From a total of 3018 studies, 16 studies were included in this paper based on our eligibility criteria, which showed promising and consistent results.
Further research concerning specific inflammatory conditions is required.
炎症是免疫系统提供的一种必要反应，可确保在微生物感染、组织损伤和其他有害情况下的生存。然而，长期的炎症过程往往与健康的严重副作用有关。
本系统评价旨在提供 2000 年至 2019 年文献中有关镓化合物的临床前和人体抗炎活性的证据，重点阐明炎症过程中涉及的机制。
检索了 7 个文献数据库（PubMed、Medline、ScienceDirect、Scopus、Springer、Web of Science 和 EBSCOhost）。本系统评价的合适出版物的选择和撰写均基于 PRISMA 声明中提到的指南。此外，还对所选研究的方法学质量进行了评估。
从总共 3018 项研究中，根据我们的纳入标准，有 16 项研究被纳入本文，这些研究显示出有前景且一致的结果。
需要针对具体的炎症情况进行进一步的研究。
