Department of Obstetrics, Chongqing Health Center for Women and Children , Chongqing, P.R. China.
Hypertens Pregnancy. 2020 Aug;39(3):336-347. doi: 10.1080/10641955.2020.1769644. Epub 2020 Jun 2.
Objective An updated meta-analysis was performed to evaluate the relationship between an insertion/deletion (I/D) polymorphism in angiotensin-converting enzyme () and preeclampsia (PE) risk. Methods Pubmed, OVID and China National Knowledge Infrastructure databases were searched. Pooled odds ratios with 95% confidence intervals were calculated using fixed-effects or random-effects model. Results ACE I/D polymorphism decreased the risk of PE in overall analysis. Subgroup analysis revealed a significantly lower risk of PE with polymorphism in Asians, Caucasians. The decreased risk was also found in severe PE and early-onset PE. Conclusion ACE I/D polymorphism may protect against the development of PE.
进行更新的荟萃分析以评估血管紧张素转换酶（ACE）中的插入/缺失（I/D）多态性与先兆子痫（PE）风险之间的关系。
检索 Pubmed、OVID 和中国国家知识基础设施数据库。使用固定效应或随机效应模型计算合并的优势比及其 95%置信区间。
ACE I/D 多态性降低了总体分析中 PE 的风险。亚组分析显示，亚洲人和白种人中的 多态性与 PE 的风险显著降低。在重度 PE 和早发型 PE 中也发现了这种降低风险的现象。
ACE I/D 多态性可能有助于预防 PE 的发生。
