J Drugs Dermatol. 2020 May 1;19(5):487-492.
Psoriasis is associated with physical, psychological, social, and economic burdens that lead to substantial impairment over a patient’s lifetime. It is important to understand how different skin clearance levels may relate to patient perceptions of psoriasis symptoms and health-related quality of life. Here, we highlight notable advantages to complete skin clearance relative to high levels of efficacy without complete skin clearance, including meaningful improvements in patient-reported signs and symptoms of psoriasis, a higher mean proportion of symptom-free days, and significant improvements in quality of life. We also review biologic therapies associated with high percentages of complete skin clearance and significant improvements in signs and symptoms of psoriasis, notably brodalumab. These therapies are likely to play important roles in the future treatment of moderate-to-severe psoriasis, given that improvement in quality of life is of significant value relative to biologics or other systemic therapies associated with lower rates of complete skin clearance. J Drugs Dermatol. 2020;19(5): doi:10.36849/JDD.2020.4957.
银屑病会给患者带来身体、心理、社会和经济等多方面负担，使其一生都深受其扰。了解不同的皮肤清除率如何与患者对银屑病症状和健康相关生活质量的认知相关，这一点很重要。在此，我们重点介绍了与无完全皮肤清除但具有高疗效相比，完全皮肤清除的显著优势，包括患者报告的银屑病症状和体征的显著改善、无病日比例的均值更高，以及生活质量的显著改善。我们还回顾了与银屑病症状和体征的显著改善相关的高比例完全皮肤清除率的生物疗法，特别是布罗达卢单抗。鉴于与较低完全皮肤清除率相关的生物制剂或其他全身治疗相比，改善生活质量具有重要价值，这些疗法可能在中重度银屑病的未来治疗中发挥重要作用。J 皮肤病药物治疗杂志。2020；19（5）：doi：10.36849/JDD.2020.4957.
