Lorencova M, Mitro A, Jurikova M, Galfiova P, Mikusova R, Krivosikova L, Janegova A, Palkovic M, Polak S
Bratisl Lek Listy. 2020;121(6):437-443. doi: 10.4149/BLL_2020_071.
The ependymal lining of the human brain ventricular system displays distinct structural differences and functional heterogeneity among individual ependymal cells (ECs). To date, multi-ciliated ECs (E1 cells), bi-ciliated ECs (E2 cells), uni-ciliated ECs (E3 cells), ECs without cilia, and ECs with cytoplasmic protrusions have been described in human brain ventricles.
Using scanning electron microscopy (SEM), we evaluated ependymal samples from 6 defined regions of the third ventricle from 9 human brains. These regions were strictly defined according to the periventricular structures they neighbour with.
We observed different structures on the apical surface of the ECs. Various ECs differed from each other by the presence of microvilli, secretory bodies, and a variable number of cilia, which led us to divide the ECs into several exactly specified types according to their apical morphology.
We found all types of ECs in every examined region with a predominance of particular types of apical surface of ECs in the individual areas (Tab. 4, Fig. 7, Ref. 22).
人类脑室系统的室管膜衬里在单个室管膜细胞（ECs）之间表现出明显的结构差异和功能异质性。迄今为止，在人类脑室中已描述了多纤毛ECs（E1细胞）、双纤毛ECs（E2细胞）、单纤毛ECs（E3细胞）、无纤毛的ECs以及具有细胞质突起的ECs。
我们使用扫描电子显微镜（SEM）评估了来自9个人脑第三脑室6个明确区域的室管膜样本。这些区域是根据它们相邻的脑室周围结构严格定义的。
我们在ECs的顶端表面观察到了不同的结构。各种ECs因微绒毛、分泌体和不同数量的纤毛的存在而彼此不同，这使我们根据其顶端形态将ECs分为几种精确指定的类型。
我们在每个检查区域都发现了所有类型的ECs，且在各个区域中特定类型的ECs顶端表面占优势（表4，图7，参考文献22）。
