Sheffield Institute of Translational Neuroscience (SITraN), Department of Neuroscience, University of Sheffield, Sheffield, UK.
Amyotroph Lateral Scler Frontotemporal Degener. 2020 Aug;21(5-6):435-444. doi: 10.1080/21678421.2020.1752246. Epub 2020 Jun 2.
Neuroinflammation, meaning the establishment of a diffuse inflammatory condition in the CNS, is one of the main hallmarks of amyotrophic lateral sclerosis (ALS). Recently, a crucial role of regulatory T cells (Tregs) in this disease has been outlined. Tregs are a T cell subpopulation with immunomodulatory properties. In this review, we discuss the physiology of Tregs and their role in ALS disease onset and progression. Evidence has demonstrated that in ALS patients Tregs are dramatically and progressively reduced in number and are less effective in promoting immune suppression. In addition, Tregs levels correlate with the rate of disease progression and patient survival. For this reason, Tregs are now considered a promising therapeutic target for neuroprotection in ALS. In this review, the clinical impact of these cells will be discussed and an overview of the current clinical trials targeting Tregs is also provided.
神经炎症是指中枢神经系统（CNS）中弥漫性炎症状态的建立，是肌萎缩侧索硬化症（ALS）的主要特征之一。最近，调节性 T 细胞（Tregs）在这种疾病中的关键作用已被概述。Tregs 是具有免疫调节特性的 T 细胞亚群。在这篇综述中，我们讨论了 Tregs 的生理学及其在 ALS 发病和进展中的作用。有证据表明，在 ALS 患者中，Tregs 的数量显著且逐渐减少，其促进免疫抑制的作用降低。此外，Tregs 水平与疾病进展速度和患者生存相关。因此，Tregs 现在被认为是 ALS 神经保护的有前途的治疗靶点。在这篇综述中，将讨论这些细胞的临床影响，并提供针对 Tregs 的当前临床试验概述。
