School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, China.
Department of Neurology, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, China.
Curr Pharm Biotechnol. 2021;22(1):182-190. doi: 10.2174/1389201021666200602134054.
The administration of many pharmaceutical active ingredients is often performed by the injection of an aqueous-based solution. Numerous active ingredients are however, insoluble in water, which complicates their administration and restricts their efficacy.
The current solutions are hindered by both, a time-consuming manufacturing process and unsuitability for hydrophilic and hydrophobic materials.
Emulsions of oleophilic active ingredients and polyprotein microspheres are an important step to overcome insolubility issues.
Polyprotein microspheres offer a versatile modifiable morphology, thermal responsivity, and size variation, which allows for the protection and release of assembled biomaterials. In addition, nanospheres present promising cell phagocytosis outcomes in vivo.
In this research, a reproducible multifunctional approach, to assemble nanospheres in one step, using a technique termed "automatic nanoscalar interfacial alternation in emulsion" (ANIAE) was developed, incorporating a thermally controlled release mechanism for the assembled target active ingredients. These results demonstrate a viable, universal, multifunctional principal for the pharmaceutical industry.
许多药物活性成分的给药方式通常是通过注射水性溶液来实现。然而，许多活性成分在水中不溶，这使得它们的给药变得复杂，并限制了它们的疗效。
目前的解决方案既受到耗时的制造工艺的限制，也受到亲水性和疏水性材料适用性的限制。
亲脂性活性成分和多蛋白微球的乳液是克服不溶性问题的重要步骤。
多蛋白微球提供了一种多功能的可修饰形态、热响应性和尺寸变化，允许组装生物材料的保护和释放。此外，纳米球在体内表现出有前途的细胞吞噬作用。
在这项研究中，开发了一种可重现的多功能方法，使用一种称为“乳液中自动纳米级界面交替”（ANIAE）的技术，一步组装纳米球，并结合了针对组装目标活性成分的热控释放机制。这些结果为制药行业展示了一种可行的、通用的多功能原理。
