Department of Pharmacology, Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada.
J Gen Physiol. 2020 Aug 3;152(8). doi: 10.1085/jgp.202012598.
Kv7 channels are powerfully regulated by a wide variety of physiological and pharmacological signals. Larsson et al. describe the direct modulation of Kv7 channels by endocannabinoids and explore how combinations of Kv7 activators with distinct subtype specificities might lead to effective and selective drug cocktails.
Kv7 通道受到多种生理和药理学信号的强烈调节。Larsson 等人描述了内源性大麻素对 Kv7 通道的直接调节，并探讨了具有不同亚型特异性的 Kv7 激活剂的组合如何可能导致有效和选择性的药物鸡尾酒。
