School of Public Health, Sun Yat-sen University, Guangzhou, China.
School of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen, China.
Cancer. 2020 Aug 15;126(16):3719-3732. doi: 10.1002/cncr.32986. Epub 2020 Jun 2.
Human papillomavirus (HPV) is associated with a substantial percentage of cervical cancer, and a significant percentage of anal, penile, vaginal, vulvar, oral cavity, oropharyngeal, and laryngeal cancers. Understanding the burden and trends of HPV-attributable cancers is crucial to HPV prevention strategies. In the current study, the authors estimated the latest burden and trends of HPV-attributable cancers in China.
Data from the following sources were used. The number of new cancer cases and cancer deaths in China were estimated based on the China Cancer Registry Annual Report. The population-attributable fraction was estimated using pooled high-risk HPV prevalence and biomarker-positive rates, which were calculated using random effects meta-analyses. Cancer burden estimates were stratified by anatomic site, sex, and age.
In 2015, a total of 110,650 new cancer cases and 36,714 cancer deaths attributable to HPV infection were estimated to have occurred in China, of which cervical cancer accounted for 85.6% and 78.1%, respectively. The age-standardized incidence rate (ASIR) and age-standardized mortality rate (ASMR) of HPV-attributable cancers were 5.63 and 1.81 per 100,000 person-years, respectively. The ASIR and ASMR both varied by anatomic site, with the highest rates noted for cervical cancer at 4.83 and 1.42 per 100,000 person-years, respectively. Between 2005 and 2015, the ASIR and ASMR demonstrated significant upward trends for all HPV-attributable cancers combined.
Between 2005 and 2015, cervical cancer accounted for the vast majority of HPV-attributable cancers and its incidence and mortality increased rapidly in China. The comprehensive prevention of cervical cancer remains the most important target in the prevention of HPV-attributable cancers.
人乳头瘤病毒（HPV）与相当大比例的宫颈癌以及相当大比例的肛门癌、阴茎癌、阴道癌、外阴癌、口腔癌、口咽癌和喉癌有关。了解 HPV 相关癌症的负担和趋势对于 HPV 预防策略至关重要。在本研究中，作者估计了中国最新的 HPV 相关癌症负担和趋势。
使用了以下来源的数据。根据《中国癌症登记年报》，估计了中国新癌症病例和癌症死亡人数。使用基于汇总高危型 HPV 流行率和生物标志物阳性率的人群归因分数进行估计，这些数据是通过随机效应荟萃分析计算得出的。根据解剖部位、性别和年龄对癌症负担估计进行分层。
2015 年，中国估计有 110650 例新的 HPV 相关癌症病例和 36714 例癌症死亡病例，其中宫颈癌分别占 85.6%和 78.1%。HPV 相关癌症的年龄标准化发病率（ASIR）和年龄标准化死亡率（ASMR）分别为每 100000 人年 5.63 和 1.81。HPV 相关癌症的 ASIR 和 ASMR 均因解剖部位而异，宫颈癌的发病率和死亡率最高，分别为每 100000 人年 4.83 和 1.42。2005 年至 2015 年期间，所有 HPV 相关癌症的 ASIR 和 ASMR 均呈显著上升趋势。
2005 年至 2015 年期间，宫颈癌占 HPV 相关癌症的绝大多数，其发病率和死亡率在中国迅速上升。全面预防宫颈癌仍然是预防 HPV 相关癌症的最重要目标。
