National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
International Agency for Research on Cancer, Lyon, France.
Cancer Med. 2020 Jan;9(1):374-384. doi: 10.1002/cam4.2697. Epub 2019 Nov 12.
Human papillomavirus (HPV) attributable cancer burden is currently unknown in China, which is essential to evaluate the potential benefit of existing HPV vaccines and to inform cancer control policy.
We extracted data of cancer incidence and mortality in 2014 from Chinese Cancer Registry Annual Report, and data of national population from National Bureau of Statistics. HPV-attributable cancer burden was estimated by incorporating cancer rates and population forecasts by sex, cancer site, age and geographical area, and then combined to corresponding population attributable fractions.
We estimated that there were 110 894 HPV-attributable new cancer cases in China in 2014, including 99 253 cervical cancers, 4449 noncervical cancers in females and 7192 cancers in males. The age-standardized incidence of HPV-attributable cancers in China was 5.69 per 100 000 persons, being slightly higher in rural than urban areas. Specifically, 51.1% of HPV-attributable cervical cancers were diagnosed in women aged 40-54 years, while 75.8% of noncervical cancers were diagnosed at 45-79 years of age. Among males, 53.4% of cancers were diagnosed at 55-74 years of age. Thirty five thousand six hundred and eighty three HPV-attributable cancer deaths were estimated, including 29 683 due to cervical cancer, and 2307 and 3693 due to noncervical cancer in females and males, respectively.
The cancer burden attributable to HPV in China is substantial. HPV vaccination and cervical screening should be prioritized.
目前尚不清楚中国的人乳头瘤病毒（HPV）相关癌症负担，这对于评估现有 HPV 疫苗的潜在效益以及为癌症防控政策提供信息至关重要。
我们从《中国癌症登记年报》中提取了 2014 年癌症发病率和死亡率数据，从国家统计局提取了全国人口数据。通过纳入按性别、癌症部位、年龄和地理区域划分的癌症发病率和人口预测数据，来估计 HPV 相关癌症负担，并将其合并为相应的人群归因分数。
我们估计 2014 年中国有 110894 例 HPV 相关新发病例，包括 99253 例宫颈癌、4449 例女性非宫颈癌和 7192 例男性癌症。中国 HPV 相关癌症的年龄标准化发病率为 5.69/100000 人，农村地区略高于城市地区。具体而言，51.1%的 HPV 相关宫颈癌发生在 40-54 岁的女性中，而 75.8%的非宫颈癌发生在 45-79 岁的女性中。在男性中，53.4%的癌症发生在 55-74 岁。估计有 3683 例 HPV 相关癌症死亡，包括 29683 例宫颈癌死亡，2307 例和 3693 例女性非宫颈癌和男性癌症死亡。
中国 HPV 相关癌症负担巨大。应优先考虑 HPV 疫苗接种和宫颈癌筛查。
