Department of Biology, Nesbitt Building, Carleton University, 1125 Colonel By Drive, Ottawa, ON K1S 5B6, Canada.
Can J Microbiol. 2020 Oct;66(10):593-599. doi: 10.1139/cjm-2020-0071. Epub 2020 Jun 2.
, the fungal pathogen that causes white-nose syndrome, has killed millions of bats across eastern North America and continues to threaten new bat populations. The spread and persistence of has likely been worsened by the ability of this fungus to grow as a saprotroph in the hibernaculum environment. Reducing the environmental growth of may improve bat survival. Volatile organic compounds (VOCs) are attractive candidates to target environmental s, as they can permeate through textured environments that may be difficult to thoroughly contact with other control mechanisms. We tested in hibernaculum sediment the performance of VOCs that were previously shown to inhibit growth in agar cultures and examined the inhibition kinetics and specificity of these compounds. Three VOCs, 2-methyl-1-butanol, 2-methyl-1-propanol, and 1-pentanol, were fungicidal towards in hibernaculum sediment, fast-acting, and had greater effects against than other species. Our results suggest that use of these VOCs may be considered further as an effective management strategy to reduce the environmental exposure of bats to in hibernacula.
导致白鼻综合征的真菌病原体已导致北美东部数百万只蝙蝠死亡,并继续威胁新的蝙蝠种群。这种真菌在冬眠环境中作为腐生物生长的能力可能使 的传播和持续存在恶化。减少 的环境生长可能会提高蝙蝠的存活率。挥发性有机化合物 (VOC) 是有吸引力的目标环境化合物,因为它们可以渗透到纹理环境中,而这些环境可能难以用其他控制机制彻底接触。我们在冬眠沉积物中测试了先前在琼脂培养物中显示出抑制 生长的 VOC 的性能,并研究了这些化合物的抑制动力学和特异性。三种 VOC,2-甲基-1-丁醇、2-甲基-1-丙醇和 1-戊醇,对冬眠沉积物中的 具有杀菌作用,作用迅速,对 比其他 种的作用更强。我们的研究结果表明,可能需要进一步考虑使用这些 VOC,作为一种有效的管理策略,以减少蝙蝠在冬眠中接触 的环境暴露。