基质金属蛋白酶-9（MMP-9）C1562T 多态性与中国人群缺血性脑卒中易感性的荟萃分析。
Meta-analysis of matrix metalloproteinase (MMP)-9 C1562T polymorphism and susceptibility to ischemic stroke in the Chinese population.
机构信息
Department of Neurology, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China.
出版信息
J Int Med Res. 2020 Jun;48(6):300060520926427. doi: 10.1177/0300060520926427.
OBJECTIVE
Many studies have shown that the C1562T polymorphism in the matrix metalloproteinase (MMP)-9 gene promoter is associated with susceptibility to ischemic stroke (IS), but the association between them remains controversial. Our objective was to explore the relationship between C1562T polymorphism and susceptibility to IS in the Chinese population.
METHODS
We conducted a database search of Wanfang, China Science and Technology Journal database, China National Knowledge Infrastructure, Medline, Embase, PubMed and Springerlink through September 2019. Meta-analysis was performed using Stata15.0 software (StataCorp LP, College Station, TX, USA).
RESULTS
Thirteen articles were included, including 3,996 patients and 3,815 controls. Among the Chinese population, the results showed no significant difference for the allele model (T vs. C; odds ratio = 1.05, 95%CI: 0.80-1.37). Significant differences were found in the dominant model (TT+TC vs. CC; odds ratio = 2.94, 95%CI: 1.58-5.45) and in the recessive model (TT vs. TC+CC; pooled OR = 0.81, 95%CI: 0.66-0.99). Neither the homozygous model or heterozygous model was significant.
CONCLUSION
We identified a correlation between MMP-9 C1562T polymorphism and IS in the Chinese population; the TT+TC genotype may increase the risk of IS.
目的
许多研究表明，基质金属蛋白酶（MMP）-9 基因启动子中的 C1562T 多态性与缺血性脑卒中（IS）易感性相关，但它们之间的关联仍存在争议。本研究旨在探讨 MMP-9 C1562T 多态性与中国人群 IS 易感性的关系。
方法
我们检索了万方、中国科技期刊数据库、中国知网、Medline、Embase、PubMed 和 Springerlink 数据库，检索时间截至 2019 年 9 月。采用 Stata15.0 软件（StataCorp LP，德克萨斯州学院站）进行 Meta 分析。
结果
共纳入 13 项研究，包括 3996 例患者和 3815 例对照。在中国人群中，等位基因模型（T 对 C）的结果显示，等位基因 T 并不增加 IS 的发病风险（比值比=1.05，95%可信区间：0.80-1.37）。显性模型（TT+TC 对 CC）和隐性模型（TT 对 TC+CC）的结果显示，TT 基因型可能增加 IS 的发病风险（优势比=2.94，95%可信区间：1.58-5.45；比值比=0.81，95%可信区间：0.66-0.99）。但未发现 TT 纯合子和 TC 杂合子模型存在统计学意义。
结论
MMP-9 C1562T 多态性与中国人群 IS 相关，TT+TC 基因型可能增加 IS 的发病风险。
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