Institute for Respiratory Health, Nedlands, WA 6009, Australia; Centre for Respiratory Health, School of Biomedical Sciences, University of Western Australia, Nedlands, WA 6009, Australia; Centre for Cell Therapy and Regenerative Medicine, School of Biomedical Sciences, University of Western Australia, Nedlands, WA 6009, Australia.
Department of Pharmacology, School of Biomedical Sciences, University of Western Australia, Nedlands, WA 6009, Australia.
Curr Opin Immunol. 2020 Jun;64:88-109. doi: 10.1016/j.coi.2020.04.005. Epub 2020 May 30.
The mesothelium when first described was thought to function purely as a non-adhesive surface to facilitate intracoelomic movement of organs. However, the mesothelium is now recognized as a dynamic cellular membrane with many important functions that maintain serosal integrity and homeostasis. For example, mesothelial cells interact with and help regulate the body's inflammatory and immune system following infection, injury, or malignancy. With recent advances in our understanding of checkpoint molecules and the advent of novel immunotherapy approaches, there has been an increase in the number of studies examining mesothelial and immune cell interaction, in particular the role of these interactions in malignant mesothelioma. This review will highlight some of the recent advances in our understanding of how mesothelial cells help regulate serosal immunity and how in a malignant environment, the immune system is hijacked to stimulate tumor growth. Ways to treat mesothelioma using immunotherapy approaches will also be discussed.
当间皮细胞最初被描述时，人们认为它的功能纯粹是作为一个非黏附表面，以促进器官在体腔内的运动。然而，间皮细胞现在被认为是一种具有许多重要功能的动态细胞膜，它可以维持浆膜的完整性和内环境稳定。例如，间皮细胞在感染、损伤或恶性肿瘤后与身体的炎症和免疫系统相互作用，并帮助其调节。随着我们对检查点分子理解的进步和新型免疫治疗方法的出现，越来越多的研究检查间皮细胞和免疫细胞的相互作用，特别是这些相互作用在恶性间皮瘤中的作用。这篇综述将强调我们在理解间皮细胞如何帮助调节浆膜免疫方面的一些最新进展，以及在恶性环境中，免疫系统是如何被劫持来刺激肿瘤生长的。也将讨论使用免疫治疗方法治疗间皮瘤的方法。
