用于环境和生物医学用途的纳米磁性颗粒生产的工业厂房的高档设计、工艺开发及经济分析。
Upscale Design, Process Development, and Economic Analysis of Industrial Plants for Nanomagnetic Particle Production for Environmental and Biomedical Use.
作者信息
Augusto Paulo A, Castelo-Grande Teresa, Vargas Diana, Pascual Alvaro, Hernández Lorenzo, Estevez Angel M, Barbosa Domingos
机构信息
Departamento de Ingeniería Química y Textil, Facultad de Ciencias Químicas, Universidad de Salamanca, Plaza de los Caídos, 1-5, 37008 Salamanca, Spain.
LEPABE-Laboratory for Process Engineering, Environment, Biotechnology and Energy, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal.
出版信息
Materials (Basel). 2020 May 29;13(11):2477. doi: 10.3390/ma13112477.
Very few economical and process engineering studies have been made concerning the scale-up and implementation of nanomagnetic particle manufacturing into a full-scale plant, and determination of its viability. In this work we describe such a study for two types of industrial plants, one for manufacturing magnetic particles for applications in the environmental area, and the other for manufacturing nanomagnetic particles for applications in the biotechnology area; the two different applications are compared. The following methodology was followed: establish the manufacturing process for each application; determine the market demand of the product (magnetic nanoparticles) for both applications; determine the production capacity of each plant; engineer all the manufacturing process, determining all the process units and performing all the mass and energy balances for both plants; scale-up the main equipment; and determine the global economic impact and profitability. At the end both plants are found to be technologically and economically viable, the characteristics of the final products being, however, quite different, as well as the process engineering, economic analysis, and scale-up.
关于将纳米磁性颗粒制造扩大规模并应用于全尺寸工厂以及确定其可行性的经济和过程工程研究非常少。在这项工作中,我们描述了针对两种类型工业工厂的此类研究,一种用于制造应用于环境领域的磁性颗粒,另一种用于制造应用于生物技术领域的纳米磁性颗粒;对这两种不同应用进行了比较。遵循了以下方法:为每种应用建立制造工艺;确定两种应用的产品(磁性纳米颗粒)的市场需求;确定每个工厂的生产能力;对所有制造工艺进行工程设计,确定所有工艺单元并对两个工厂进行所有质量和能量平衡计算;扩大主要设备规模;并确定全球经济影响和盈利能力。最后发现两个工厂在技术和经济上都是可行的,然而,最终产品的特性以及过程工程、经济分析和扩大规模情况却有很大不同。