Neugeneron, Dallas, TX 75243, USA.
Exp Biol Med (Maywood). 2020 Jul;245(13):1130-1141. doi: 10.1177/1535370220928278. Epub 2020 Jun 2.
Brain development and degeneration are highly complex processes that are regulated by a large number of molecules and signaling pathways the identities of which are being unraveled. Accumulating evidence points to histone deacetylases and epigenetic mechanisms as being important regulators of these processes. In this review, we describe that histone deacetylase-3 (HDAC3) is a particularly crucial regulator of both neurodevelopment and neurodegeneration. In addition, HDAC3 regulates memory formation, synaptic plasticity, and the cognitive impairment associated with normal aging. Understanding how HDAC3 functions contributes to the normal development and functioning of the brain while also promoting neurodegeneration could lead to the development of therapeutic approaches for neurodevelopmental, neuropsychiatric, and neurodegenerative disorders.
大脑发育和退化是高度复杂的过程，受大量分子和信号通路的调控，这些分子和信号通路的特性正在被逐步揭示。越来越多的证据表明组蛋白去乙酰化酶和表观遗传机制是这些过程的重要调节因子。在这篇综述中，我们描述了组蛋白去乙酰化酶-3（HDAC3）是神经发育和神经退行性变的一个特别关键的调节因子。此外，HDAC3 还调节记忆形成、突触可塑性以及与正常衰老相关的认知障碍。了解 HDAC3 的功能不仅有助于大脑的正常发育和功能，还可能导致神经发育、神经精神和神经退行性疾病治疗方法的发展。
