Ding Yanwen, Liu Chengxi, Zhang Yi
Department of Anesthesiology The Second Affiliated Hospital of Zunyi Medical University Zunyi Guizhou China.
Guizhou Key Laboratory of Anesthesia and Organ Protection Zunyi Medical University Zunyi Guizhou China.
Ibrain. 2023 May 17;9(2):205-213. doi: 10.1002/ibra.12106. eCollection 2023 Summer.
Aging can be defined as a decline of physiological function that is more difficult to reverse, characterized by the loss of the physiological integrity of tissues, organs, and cells of an organism over time. Normal aging is associated with structural and functional changes in the brain, involving neuronal apoptosis, synaptic structure, neurotransmission, and metabolism alterations, leading to impairment in sleep, cognitive functions, memory, learning, and motor and sensory systems. Histone modification is a significant aging-related epigenetic change that influences synaptic and mitochondrial function and immune and stress responses in the brain. This review discusses the changes in histone modifications that occur during brain aging, specifically methylation and acetylation, and the associated changes in gene transcription and protein expression. We observed that genes related to synaptic and mitochondrial function are downregulated in the aging brain, while genes related to immune response and inflammatory functions are upregulated.
衰老可被定义为一种更难逆转的生理功能衰退，其特征是生物体的组织、器官和细胞的生理完整性随时间丧失。正常衰老与大脑的结构和功能变化相关，包括神经元凋亡、突触结构、神经传递和代谢改变，导致睡眠、认知功能、记忆、学习以及运动和感觉系统受损。组蛋白修饰是一种与衰老相关的重要表观遗传变化，它影响大脑中的突触和线粒体功能以及免疫和应激反应。本综述讨论了大脑衰老过程中发生的组蛋白修饰变化，特别是甲基化和乙酰化，以及相关的基因转录和蛋白质表达变化。我们观察到，与突触和线粒体功能相关的基因在衰老大脑中下调，而与免疫反应和炎症功能相关的基因上调。
