Department of Chemistry, Thiagarajar College, Madurai 625 009, Tamil Nadu, India.
Department of Chemistry, Thiagarajar College, Madurai 625 009, Tamil Nadu, India.
Mater Sci Eng C Mater Biol Appl. 2020 Aug;113:111010. doi: 10.1016/j.msec.2020.111010. Epub 2020 Apr 23.
The measurement of renal function by important clinical parameters such as (Crt) clearance and glomerular filtration rate often goes wrong vis-à-vis the Crt level in human body. Hence, development of an accurate detection system over a wide range of Crt concentration in both blood and urine is medically essential. In this study, a new non-enzymatic electrochemical probe, carbon dots doped tungstic anhydride embedded on graphene oxide nanopanels (CDs/WO@GO) is reported for picomolar-level Crt detection in blood and urine with a wide linear range (0.2-112.0 nM). The sensor is economical, reproducible, stable and interferents-free. The properties of CDs/WO@GO were studied using various analytical techniques. The proposed electrochemical Crt sensor could be used as a sustainable alternative for diagnostic use.
通过（Crt）清除率和肾小球滤过率等重要临床参数来测量肾功能往往与人体中的 Crt 水平存在偏差。因此，开发一种能够在血液和尿液中广泛的 Crt 浓度范围内进行精确检测的系统在医学上是非常必要的。在这项研究中，我们报道了一种新型的非酶电化学探针，即掺杂在氧化石墨烯纳米片上的碳化钨纳米点（CDs/WO@GO），可用于在血液和尿液中进行皮摩尔级别的 Crt 检测，具有较宽的线性范围（0.2-112.0 nM）。该传感器具有经济、可重现、稳定和无干扰的特点。利用各种分析技术对 CDs/WO@GO 的性能进行了研究。所提出的电化学 Crt 传感器可以作为一种可持续的替代诊断方法。
