Department of Psychiatry, University of British Columbia, Canada.
School of Nursing, The University of Hong Kong, Hong Kong.
Schizophr Res. 2020 Sep;223:87-95. doi: 10.1016/j.schres.2020.05.043. Epub 2020 May 30.
Individuals with early psychosis may have prefrontal-limbic cortical deficits, which are associated with symptom severity and cognitive impairment. This study investigated the impact of an exercise intervention on fronto-temporal cortical plasticity in female participants with early psychosis.
In a cohort of 51 female participants with early psychosis from Hong Kong, we investigated the effects of a 12-week, moderate intensity aerobic or Hatha yoga exercise trial (yoga (N = 21), aerobic (N = 18) or waitlist group (N = 12)) on cortical grey matter. Clinical assessments and structural MRI were completed pre- and post- a 12-week exercise intervention.
Increases in cortical volume and thickness were observed in the medial temporal cortical regions, primarily in fusiform cortical thickness (F(2, 48) = 4.221, p = 0.020, η = 0.150) and volume (F(2, 48) = 3.521, p = 0.037, η = 0.128) for participants with early psychosis in the aerobic arm, but not in the yoga and waitlist arms. Increased fusiform cortical thickness (ß = 0.402, p = 0.003) was associated with increased hippocampal volume for all psychosis participants. For the aerobic group only, increases in the entorhinal and fusiform temporal gyri were associated with reduced symptom severity.
These findings suggest exercise-induced neuroplasticity in medial temporal cortical regions occurs with aerobic exercise. These changes may be associated with improvements in psychosis symptom severity. People with early psychosis may benefit from exercise interventions, particularly aerobic exercise, as an adjunct treatment to address clinical, physical health, and neuroanatomic concerns. NIH National Library of Medicine ClinicalTrials.gov Registration #: NCT01207219https://clinicaltrials.gov/ct2/show/NCT01207219.
早期精神病患者可能存在前额-边缘皮质功能缺陷，这与症状严重程度和认知障碍有关。本研究调查了一项运动干预对女性早期精神病患者额颞皮质可塑性的影响。
在香港的 51 名早期精神病女性患者队列中，我们研究了 12 周中等强度有氧运动或哈他瑜伽运动试验（瑜伽（N=21）、有氧运动（N=18）或候补组（N=12））对皮质灰质的影响。在 12 周的运动干预前后完成了临床评估和结构磁共振成像。
在额颞皮质区域，尤其是在梭状回皮质厚度（F(2, 48)=4.221，p=0.020，η=0.150）和体积（F(2, 48)=3.521，p=0.037，η=0.128）方面，有氧运动组的早期精神病患者的皮质体积和厚度增加，但瑜伽组和候补组没有。梭状回皮质厚度的增加（ß=0.402，p=0.003）与所有精神病患者的海马体积增加有关。仅在有氧运动组中，内嗅皮质和梭状回颞叶的增加与症状严重程度的降低有关。
这些发现表明，有氧运动可引起内侧颞叶皮质区域的神经可塑性。这些变化可能与精神病症状严重程度的改善有关。早期精神病患者可能受益于运动干预，尤其是有氧运动，作为一种辅助治疗方法，以解决临床、身体健康和神经解剖问题。NIH 美国国立卫生研究院国家医学图书馆临床试验注册 #: NCT01207219https://clinicaltrials.gov/ct2/show/NCT01207219。
