鞣酸通过诱导 G/G 细胞周期阻滞和内在凋亡抑制非小细胞肺癌（NSCLC）干细胞特性。
Tannic Acid Inhibits Non-small Cell Lung Cancer (NSCLC) Stemness by Inducing G/G Cell Cycle Arrest and Intrinsic Apoptosis.
机构信息
Department of Pathology, School of Medicine, Institute of Biomedical Science and Technology, Konkuk University, Seoul, Republic of Korea.
Department of Immunology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
出版信息
Anticancer Res. 2020 Jun;40(6):3209-3220. doi: 10.21873/anticanres.14302.
BACKGROUND/AIM: Non-small cell lung cancer (NSCLC) is one among the most common cancers worldwide. Recently, dietary phytochemicals have been reported as an attractive approach to improve the symptoms of NSCLC patients. Tannic acid is a natural polyphenol, which is known to have anticancer effects on in vitro models of breast, gingival and colon cancer. However, the molecular mechanisms associated with the actions of tannic acid on A549 human lung cancer cells have not been elucidated.
MATERIALS AND METHODS
In this study, we analyzed the effect of tannic acid on A549 cells and their underlying mechanisms using western blotting, flow cytometry, invasion assay and tumorsphere formation assay.
RESULTS
Tannic acid treatment suppressed the viability of A549 cells through cell cycle arrest and induction of the intrinsic pathways of apoptosis. In addition, the various malignant phenotypes of A549 cells including invasion, migration, and stemness were inhibited by tannic acid treatment.
CONCLUSION
Tannic acid could be used as an effective inhibitor of lung cancer progression.
背景/目的：非小细胞肺癌（NSCLC）是全球最常见的癌症之一。最近，膳食植物化学物质被报道为改善 NSCLC 患者症状的一种有吸引力的方法。单宁酸是一种天然多酚，已知对体外乳腺癌、牙龈癌和结肠癌模型具有抗癌作用。然而，单宁酸对 A549 人肺癌细胞作用的分子机制尚未阐明。
材料和方法
在这项研究中，我们使用 Western blot、流式细胞术、侵袭试验和肿瘤球形成试验分析了单宁酸对 A549 细胞的影响及其潜在机制。
结果
单宁酸处理通过细胞周期阻滞和诱导内在凋亡途径抑制 A549 细胞的活力。此外，单宁酸处理还抑制了 A549 细胞的各种恶性表型，包括侵袭、迁移和干性。
结论
单宁酸可用作肺癌进展的有效抑制剂。
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