Tajiri H, Oguro Y, Egawa S, Sugimura T
Department of Internal Medicine, National Cancer Center Hospital, Tokyo, Japan.
Hokkaido Igaku Zasshi. 1988 Nov;63(6):889-96.
The use of local interstitial hyperthermia using a low powered Nd: YAG laser (known as laserthermia) has been studied both in vivo and in vitro on two gastrointestinal carcinomas. Human pancreatic carcinoma subcutaneously transplanted into nude mice (n = 28) was treated using an interstitially placed frosted sapphire probe with a Nd: YAG laser at 3 watts maintaining a temperature increase of 42 degrees C - 43 degrees C for up to 20 minutes. Seven days after treatment, a marked necrosis of the pancreatic tumor was found resembling an ischemic infarction. The potential cytocidal effect of heat and low powered Nd: YAG laser energy was also tested in vitro using three different kinds of human gastric and pancreatic cancer cells. The cytocidal effect of heat was potentiated by the photolytic effect of the low powered Nd: YAG laser energy.
使用低功率钕钇铝石榴石激光进行局部间质热疗（即激光热疗）已在两种胃肠道癌的体内和体外进行了研究。将人胰腺癌皮下移植到裸鼠体内（n = 28），使用带有钕钇铝石榴石激光的间隙放置磨砂蓝宝石探头进行治疗，功率为3瓦，将温度升高42摄氏度至43摄氏度，持续20分钟。治疗7天后，发现胰腺肿瘤出现明显坏死，类似于缺血性梗死。还使用三种不同类型的人胃癌和胰腺癌细胞在体外测试了热和低功率钕钇铝石榴石激光能量的潜在杀细胞作用。低功率钕钇铝石榴石激光能量的光解作用增强了热的杀细胞作用。
