Ohyama M, Nobori T, Furuta S, Moriyama I
Dept. of Otolaryngology, Kagoshima University, Faculty of Medicine.
Gan To Kagaku Ryoho. 1988 Apr;15(4 Pt 2-2):1401-6.
A synthetic ceramic probe allows a wider angle of irradiation and diffusion of low power energy, below 3W, using an interstitial technique for producing local hyperthermia of Nd: YAG laser (Laserthermia). We studied the influences of this laserthermia procedure in experimental animals and patients with head and neck cancer. The histological findings after laserthermia in the rabbit tongues showed no marked tissue damage in the heated area. Biochemical analysis of arachidonic acid cascade metabolites in these tissues revealed an immediate increase of 12-, 15- HETEs and PGE2 and 3 at days after hyperthermia, but at 8 days these metabolites returned to control levels. The effectiveness of laserthermia on human thyroid cancer implanted in nude mice was compared with that in cisplatin treatment and in combined therapy with both. The most predominant effectiveness was found in the animals receiving therapy combining cisplatin and laserthermia. Laserthermia in combination with radio-chemotherapy was applied in 21 cases with head and neck cancer. Good efficacy was obtained in 17 patients, especially in those with oropharyngeal cancer, showing CR in 4 cases and PR in 13 cases.
一种合成陶瓷探头采用间质技术产生Nd:YAG激光局部热疗（激光热疗），可实现低功率能量（低于3W）更宽角度的照射和扩散。我们研究了这种激光热疗程序对实验动物和头颈癌患者的影响。兔舌激光热疗后的组织学检查结果显示，受热区域无明显组织损伤。对这些组织中花生四烯酸级联代谢产物的生化分析表明，热疗后数天，12-、15-羟基二十碳四烯酸（HETEs）和前列腺素E2及E3立即增加，但在第8天这些代谢产物恢复到对照水平。将激光热疗对裸鼠移植人甲状腺癌的疗效与顺铂治疗及两者联合治疗的疗效进行了比较。在接受顺铂和激光热疗联合治疗的动物中发现疗效最为显著。21例头颈癌患者采用激光热疗联合放化疗。17例患者取得了良好疗效，尤其是口咽癌患者，4例完全缓解（CR），13例部分缓解（PR）。
