Fries Frederik, Maßmann Alexander, Tomori Toshiki, Yilmaz Umut, Kettner Michael, Simgen Andreas, Cattaneo Giorgio, Wagenpfeil Gudrun, Reith Wolfgang, Mühl-Benninghaus Ruben
Department of Neuroradiology, Saarland University Hospital and Saarland University Faculty of Medicine, Homburg, Saarland, Germany.
Department of Radiology, Saarland University Hospital and Saarland University Faculty of Medicine, Homburg, Saarland, Germany.
J Neurointerv Surg. 2020 Dec;12(12):1242-1246. doi: 10.1136/neurintsurg-2020-016129. Epub 2020 Jun 2.
Optical coherence tomography (OCT) is an ultra-high resolution real-time intravascular imaging method that is gaining interest in cerebrovascular applications.
To compare, in a rabbit elastase aneurysm model, digital subtraction angiography (DSA) and OCT as diagnostic tools for the assessment of aneurysmal remnants and baseline characteristics of aneurysms after flow diverter (FD) implantation.
With Institutional Animal Care and Use Committee approval, saccular aneurysms were created in 28 rabbits and treated with Derivo FDs. DSA was performed before, and immediately after, stent implantation. As a follow-up, DSA and OCT were performed 28 days after device implantation.
DSA and OCT were successfully performed in 23 cases. OCT could not be achieved in 5 cases owing to navigational difficulties in the stent lumen with the OCT catheter. Residual aneurysms were significantly more often visible with OCT (18/23 (78%) than with DSA 12/23 (52%), p = 0.031).
OCT was more sensitive than conventional angiography for the assessment of residual aneurysms at 28 days after FD implantation in an animal model.
光学相干断层扫描（OCT）是一种超高分辨率实时血管内成像方法，在脑血管应用中越来越受到关注。
在兔弹性蛋白酶诱导的动脉瘤模型中，比较数字减影血管造影（DSA）和OCT作为诊断工具评估血流导向装置（FD）植入后动脉瘤残余情况及动脉瘤基线特征。
经机构动物护理和使用委员会批准，在28只兔中制造囊状动脉瘤并使用Derivo血流导向装置进行治疗。在支架植入前和植入后立即进行DSA。作为随访，在装置植入后28天进行DSA和OCT检查。
23例成功进行了DSA和OCT检查。5例由于OCT导管在支架管腔内导航困难而未能完成OCT检查。OCT显示残余动脉瘤的比例（18/23，78%）显著高于DSA（12/23, 52%）（p = 0.031）。
在动物模型中，FD植入后28天，OCT对残余动脉瘤评估比传统血管造影更敏感。
