我们是如何理解脂质双层膜的“动荡的化学不均匀性”的。
How We Came to Understand the "Tumultuous Chemical Heterogeneity" of the Lipid Bilayer Membrane.
机构信息
Department of Biochemistry and Molecular Biology, Tulane University, New Orleans, LA, 70112, USA.
出版信息
J Membr Biol. 2020 Jun;253(3):185-190. doi: 10.1007/s00232-020-00126-1. Epub 2020 Jun 3.
Abstract
The path to our modern understanding of the structure of the lipid bilayer membrane is a long one that can be traced from today perhaps as far back as Benjamin Franklin in the eighteenth century. Here, I provide a personal account of one of the important steps in that path, the description of the "Complete Structure" of a hydrated, fluid phase dioleoyl phosphatidylcholine bilayer by the joint refinement of neutron and X-ray diffraction data by Stephen White and his colleagues.
摘要
我们对脂质双层膜结构的现代理解之路漫长，或许可以追溯到 18 世纪的本杰明·富兰克林。在这里，我将讲述这条道路上的重要一步，即斯蒂芬·怀特（Stephen White）及其同事通过联合解析中子和 X 射线衍射数据，描述水合、流态二油酰基磷脂酰胆碱双层的“完整结构”。
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