Zhou Zhen-Yu, Yu Xuan, Liu Hong, Wang Meng
Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine Tianjin 301617, China.
Zhongguo Zhong Yao Za Zhi. 2020 Apr;45(7):1611-1619. doi: 10.19540/j.cnki.cjcmm.20200207.307.
Ingredients with the anti-tumor property from traditional Chinese medicine/natural products have effects in treating tumor by regulating immune function, inhibiting tumor cell growth, inducing apoptosis, and reversing multidrug resistance. However, the potential of clinical application was restricted by the low hydrophilicity, stability and bioavailability and the lack of targeting. The above problems can be solved through research and development of supramolecular chemistry based on the non-covalent interactions between molecules. The supramolecular macrocyclic host molecules are characterized by a special cavity structure, low toxicity, high stability and rich derivatives spot. The anti-tumor supramolecular drug delivery system loading traditional Chinese medicine/natural products were designed to solve the above problems. In this paper, different supramolecular macrocyclic molecules, including crown ethers, cyclodextrin, calixarene, cucurbituril and two new-type supramolecular macrocyclic hosts were introduced. Their inclusion in enhancing drug solubility and stability, targeting drug delivery, synergies, combinative administration and new-type therapies in different applications, as well as such drug load modes as supramolecular polymers, indirect combination drug mode and polyrotaxanes were also reviewed in this paper, in order to provide a new idea for effective drug utilization.
来自中药/天然产物的具有抗肿瘤特性的成分可通过调节免疫功能、抑制肿瘤细胞生长、诱导凋亡以及逆转多药耐药性来治疗肿瘤。然而，其临床应用潜力受到低亲水性、稳定性和生物利用度以及缺乏靶向性的限制。基于分子间非共价相互作用的超分子化学研究与开发可以解决上述问题。超分子大环主体分子具有特殊的空腔结构、低毒性、高稳定性和丰富的衍生位点。负载中药/天然产物的抗肿瘤超分子药物递送系统旨在解决上述问题。本文介绍了不同的超分子大环分子，包括冠醚、环糊精、杯芳烃、葫芦脲以及两种新型超分子大环主体。还综述了它们在不同应用中增强药物溶解性和稳定性、靶向药物递送、协同作用、联合给药和新型治疗方面的包合作用，以及超分子聚合物、间接联合药物模式和聚轮烷等药物负载模式，以期为有效利用药物提供新思路。
