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芹黄素C通过激活沉默调节蛋白1抑制非小细胞肺癌细胞中缺氧诱导的环氧化酶-2表达。

Avenanthramide C suppresses hypoxia-induced cyclooxygenase-2 expression through sirtuin1 activation in non-small-cell lung cancer cells.

作者信息

Lim Wonchung, Kang Chounghun

机构信息

Department of Sports Medicine, College of Health Science, Cheongju University, Cheongju, South Korea.

Department of Physical Education, Inha University, Incheon, South Korea.

出版信息

Anim Cells Syst (Seoul). 2020 Apr 2;24(2):79-83. doi: 10.1080/19768354.2020.1748108. eCollection 2020.

DOI:10.1080/19768354.2020.1748108
PMID:32489686
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7241542/
Abstract

Avenanthramide C (AVC), found mainly in oats, mediates anti-inflammatory activities by reducing the anti-inflammatory cytokine levels. This study investigated the effects of AVC on hypoxia-induced cyclooxygenase-2 (COX-2) expression in A549 cells. AVC suppressed the hypoxia-induced increase in COX-2 protein levels and promoter activity. We also observed that the effects of AVC were reversed by a SIRT1 inhibitor, indicating that the inhibitory effects of AVC on hypoxia-induced COX-2 expression are mediated by SIRT1. Therefore, AVC inhibits the hypoxic induction of COX-2 expression via SIRT1 activation. Our results suggest that AVC could be beneficial for preventing lung inflammation under hypoxia.

摘要

主要存在于燕麦中的 avenanthramide C（AVC）通过降低抗炎细胞因子水平来介导抗炎活性。本研究调查了 AVC 对 A549 细胞中缺氧诱导的环氧化酶 -2（COX-2）表达的影响。AVC 抑制了缺氧诱导的 COX-2 蛋白水平升高和启动子活性。我们还观察到 SIRT1 抑制剂可逆转 AVC 的作用，表明 AVC 对缺氧诱导的 COX-2 表达的抑制作用是由 SIRT1 介导的。因此，AVC 通过激活 SIRT1 抑制缺氧诱导的 COX-2 表达。我们的结果表明，AVC 可能有助于预防缺氧状态下的肺部炎症。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e445/7241542/d76c577e6840/TACS_A_1748108_F0003_OB.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e445/7241542/fc8fbe071d84/TACS_A_1748108_F0001_OB.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e445/7241542/2c1b7b240a8b/TACS_A_1748108_F0002_OB.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e445/7241542/d76c577e6840/TACS_A_1748108_F0003_OB.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e445/7241542/fc8fbe071d84/TACS_A_1748108_F0001_OB.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e445/7241542/2c1b7b240a8b/TACS_A_1748108_F0002_OB.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e445/7241542/d76c577e6840/TACS_A_1748108_F0003_OB.jpg

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