Sabaka Peter, Kachlíková Mária, Bendžala Matej, Stankovič Igor
Department of Infectology, Geographical Medicine, Faculty, of Medicine, Comenius University in Bratislava, Slovak Republic.
Department of Infectology and Geographical Medicine, Faculty of Medicine, Comenius University in Bratislava, Limbova 5, 831 01, Slovak Republic.
IDCases. 2020 May 15;21:e00827. doi: 10.1016/j.idcr.2020.e00827. eCollection 2020.
Invasive non-typhoidal Salmonella (NTS) infections are rare in developed countries but their incidence is increasing. One of the most severe complications of extraintestinal NTS infection is mycotic aneurysm. Its natural course is usually fatal and its treatment demands complex interdisciplinary management. We present a case of severe NTS sepsis complicated by mycotic aneurysm of the abdominal aorta and left internal iliac artery and obstructive pyelonephritis. Obstruction of the left ureter was caused by pressure from the left internal iliac artery aneurysm and surrounding edema. The patient presented with clinical symptoms of sepsis and pyelonephritis. Despite abdominal ultrasound and native computed tomography, the mycotic aneurysm eluded initial examination. It remained undiagnosed until the patient presented with recurrent symptoms after stopping 17 days of antimicrobial treatment and was finally revealed by magnetic resonance imaging and contrast computed tomography. The patient was successfully treated by ligation of the left internal iliac artery, partial extirpation of the aneurysm and prolonged parenteral antimicrobial treatment. This case raises concerns that mycotic aneurysm might be present in cases of obstructive pyelonephritis caused by NTS and its early recognition is vital for appropriate management.
侵袭性非伤寒沙门氏菌(NTS)感染在发达国家较为罕见,但发病率正在上升。肠外NTS感染最严重的并发症之一是真菌性动脉瘤。其自然病程通常是致命的,其治疗需要复杂的多学科管理。我们报告一例严重的NTS败血症,并发腹主动脉和左髂内动脉真菌性动脉瘤及梗阻性肾盂肾炎。左输尿管梗阻是由左髂内动脉瘤及其周围水肿压迫所致。患者表现出败血症和肾盂肾炎的临床症状。尽管进行了腹部超声和普通计算机断层扫描,但最初的检查未能发现真菌性动脉瘤。在停止抗菌治疗17天后患者出现复发症状时,真菌性动脉瘤仍未被诊断出来,最终通过磁共振成像和增强计算机断层扫描才得以发现。患者通过结扎左髂内动脉、部分切除动脉瘤以及延长肠外抗菌治疗而成功治愈。该病例引发了人们的担忧,即在由NTS引起的梗阻性肾盂肾炎病例中可能存在真菌性动脉瘤,其早期识别对于恰当的治疗至关重要。