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真菌性动脉瘤:罕见病原体与治疗难题

Mycotic aneurysms: uncommon pathogens and treatment conundrums.

作者信息

Ravindra Akshatha, Naguthevar Santhanam, Kumar Deepak, Rajagopal Rengarajan, Khera Pushpinder Singh, Tak Vibhor, Ramankutty Neetha Thayil, Meena Durga Shankar, Midha Naresh, Bohra Gopal Krishana, Garg Mahendra Kumar

机构信息

Department of Medicine and Infectious Diseases, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.

Department of Diagnostic and Interventional Radiology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.

出版信息

Access Microbiol. 2024 Aug 20;6(8). doi: 10.1099/acmi.0.000777.v5. eCollection 2024.

Abstract

Mycotic aneurysms, characterized by vessel wall dilation resulting from infections including bacteria, fungi, and viruses, are a rare but severe consequence of systemic infections. The term 'mycotic' was coined by William Osler to describe the first instance of a fungal-induced infected aneurysm. These aneurysms, accounting for 0.6% of aneurysms in Western countries, carry a higher risk of rupture compared to uninfected aneurysms. While the femoral artery, aorta, and intracranial arteries are commonly affected, pathogens causing mycotic aneurysms vary across regions. Diagnostic challenges arise from nonspecific symptoms such as fever, and discomfort. To prevent the substantial morbidity and mortality associated with mycotic aneurysms, timely identification and treatment are paramount. We present a case series highlighting mycotic aneurysms caused by some rare pathogens - , and . This case series involves three patients diagnosed with mycotic aneurysms due to unusual pathogens. We describe each patient's clinical presentation, medical history, physical examination findings, laboratory results, imaging studies, and the diagnostic process leading to the identification of the causative pathogens. The first patient is a 70-year-old gentleman who presented with a ruptured infra-renal abdominal aortic pseudoaneurysm caused by . The second patient is a 66-year-old gentleman with a -associated descending thoracic aortic pseudoaneurysm. The third patient is a 70-year-old gentleman with a ruptured descending thoracic aortic aneurysm with an occult aorto-oesophageal fistula due to infection. The description highlights unique clinical features, laboratory findings, imaging results, and the management approaches undertaken in each patient. Mycotic aneurysms, pose diagnostic challenges due to their nonspecific symptoms. Early identification and intervention are essential to mitigate the severe complications associated with these aneurysms. The presented cases underscore the need for a comprehensive approach to diagnosis and management, ensuring optimal outcomes for patients affected by mycotic aneurysms.

摘要

真菌性动脉瘤是由包括细菌、真菌和病毒在内的感染导致血管壁扩张所引起的,是全身感染罕见但严重的后果。“真菌性”一词由威廉·奥斯勒创造,用于描述首例真菌引起的感染性动脉瘤。这些动脉瘤在西方国家占动脉瘤的0.6%,与未感染的动脉瘤相比,破裂风险更高。虽然股动脉、主动脉和颅内动脉是常见的受累部位,但不同地区引起真菌性动脉瘤的病原体有所不同。诊断面临挑战,因为存在发热和不适等非特异性症状。为预防与真菌性动脉瘤相关的严重发病率和死亡率,及时识别和治疗至关重要。我们展示了一系列病例,突出了由一些罕见病原体——和——引起的真菌性动脉瘤。本病例系列涉及三名因不寻常病原体被诊断为真菌性动脉瘤的患者。我们描述了每位患者的临床表现、病史、体格检查结果、实验室检查结果、影像学研究以及导致确定致病病原体的诊断过程。第一名患者是一名70岁男性,因……出现肾下腹主动脉假性动脉瘤破裂。第二名患者是一名66岁男性,患有与……相关的降主动脉假性动脉瘤。第三名患者是一名70岁男性,因……感染出现降主动脉瘤破裂并伴有隐匿性主动脉食管瘘。该描述突出了每位患者独特的临床特征、实验室检查结果、影像学结果以及所采取的管理方法。真菌性动脉瘤因其非特异性症状而带来诊断挑战。早期识别和干预对于减轻与这些动脉瘤相关的严重并发症至关重要。所展示的病例强调了采用综合诊断和管理方法的必要性,以确保受真菌性动脉瘤影响的患者获得最佳治疗效果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ae9/11334579/cce554d29d71/acmi-6-00777-g001.jpg

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