Ludwig Nils, Jackson Edwin K, Whiteside Theresa L
Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA.
Vessel Plus. 2020;4. doi: 10.20517/2574-1209.2019.37. Epub 2020 Apr 10.
The role of exosomes in different physiological and pathological settings is an emerging field of great current interest. One hallmark of exosomes is the promotion of blood vessel formation. Exosomes of different cellular origin have been shown to be enriched in angiogenic proteins which directly promote angiogenesis. In addition, exosomes are also efficacious producers of adenosine and potentially encapsulate adenosine in their lumen. The adenosine content of exosomes has been linked to their immunosuppressive effects. In this communication, we consider the possibility that adenosine production by tumor cell-derived exosomes may represent a novel pathway for stimulation of angiogenesis in the tumor microenvironment.
外泌体在不同生理和病理环境中的作用是当前一个备受关注的新兴领域。外泌体的一个显著特征是促进血管生成。已表明不同细胞来源的外泌体富含直接促进血管生成的血管生成蛋白。此外，外泌体也是腺苷的有效生产者，并且可能在其腔内包裹腺苷。外泌体中的腺苷含量与其免疫抑制作用有关。在本通讯中，我们考虑肿瘤细胞衍生的外泌体产生腺苷可能代表肿瘤微环境中刺激血管生成的一条新途径的可能性。
