Di Mauro Michele, Scrofani Roberto, Antona Carlo, Nicolò Francesca, Cappabianca Giangiuseppe, Beghi Cesare, Santarpino Giuseppe, Gregorini Renato, Di Marco Luca, Pacini Davide, Salsano Antonio, Santini Francesco, Weltert Luca, De Paulis Ruggero, Pano Marco, Zaccaria Salvatore, D'Alfonso Alessandro, Di Eusanio Marco, Massi Francesco, Portoghese Michele, Stura Erik Cura, Rinaldi Mauro, Margari Vito, Foschi Massimiliano, Parolari Alessandro, Paparella Domenico
Cardio-Thoracic Surgery Unit, Heart and Vascular Centre, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Centre (MUMC), Maastricht, The Netherland.
Department of Cardiac Surgery, "Fatebenefratelli-Sacco" Hospital, University of Milan, Milan, Italy.
J Card Surg. 2020 Jul;35(7):1548-1555. doi: 10.1111/jocs.14672. Epub 2020 Jun 3.
The aim of this multicenter prospective study was to evaluate the prognostic weight of preoperative right ventricular assessment on early mortality in cardiac surgery.
This is a multicenter prospective observational study performed by the Italian Group of Research for Outcome in Cardiac Surgery (GIROC) including 11 centers. From October 2017 to March 2019, out of 923 patients undergoing cardiac surgery, 28 patients with some missing data were excluded and 895 patients were enrolled in the study right ventricular dilatation was defined as a basal end-diastolic diameter >42 mm. The right ventricle (RV) function was assessed using the combination of three parameters: fractional area changing (FAC), tricuspid annular plane systolic excursion (TAPSE), and S'-wave using tissue Doppler imaging (TDI-S'); RV dysfunction was defined as the presence of at least two of the following cutoffs: FAC <35%, TAPSE <17 mm, and TDI S' <9.5 mm RESULTS: Among the entire cohort, 624 (70%) showed normal RV, 92 (10%) isolated RV dilatation, 154 (17%) isolated RV dysfunction, and 25 (3%) both RV dilatation and dysfunction. Non-surviving patients showed a significantly higher rate of RV alteration at multivariable analysis, RV status was found to be an independent predictor for higher in-hospital mortality beside Euroscore II.
This prospective multicenter observation study shows the importance to assess RV preoperatively and to include both RV function and dimension in a risk score model such as Euroscore II to implement its predictivity, since PH cannot always mirror the status of the right ventricle.
这项多中心前瞻性研究的目的是评估术前右心室评估对心脏手术早期死亡率的预后权重。
这是一项由意大利心脏手术结果研究组(GIROC)进行的多中心前瞻性观察性研究,包括11个中心。2017年10月至2019年3月,在923例接受心脏手术的患者中,排除28例有一些缺失数据的患者,895例患者纳入研究。右心室扩张定义为基础舒张末期直径>42 mm。使用三个参数的组合评估右心室(RV)功能:面积变化分数(FAC)、三尖瓣环平面收缩期位移(TAPSE)和组织多普勒成像的S波(TDI-S');RV功能障碍定义为存在以下至少两个临界值:FAC<35%、TAPSE<17 mm和TDI S'<9.5 mm。结果:在整个队列中,624例(70%)显示RV正常,92例(10%)孤立性RV扩张,154例(17%)孤立性RV功能障碍,25例(3%)既有RV扩张又有功能障碍。在多变量分析中,非存活患者显示RV改变的发生率显著更高,发现RV状态是除欧洲心脏手术风险评估系统II(Euroscore II)之外住院死亡率较高的独立预测因素。
这项前瞻性多中心观察性研究表明术前评估RV以及将RV功能和尺寸纳入诸如Euroscore II等风险评分模型以提高其预测性的重要性,因为肺动脉高压(PH)并不总能反映右心室的状态。