[偏执型精神分裂症和阿尔茨海默病中中性粒细胞的功能活性]
[The functional activity of neutrophils in paranoid schizophrenia and Alzheimer's disease].
作者信息
Proskurnina E V, Sokolova S V, Grishina N K, Sozarukova M M, Gaifullin N M, Khannanova A N
机构信息
Research Centre of Medical Genetics, Moscow, Russia.
Lomonosov Moscow State University, Moscow, Russia.
出版信息
Zh Nevrol Psikhiatr Im S S Korsakova. 2020;120(4):97-101. doi: 10.17116/jnevro202012004197.
OBJECTIVE
To evaluate the radical-producing function of neutrophils in paranoid schizophrenia and Alzheimer's disease.
MATERIAL AND METHODS
The study included 40 patients with paranoid schizophrenia and 22 with Alzheimer's disease. To assess the functional activity of neutrophils, whole blood samples were analyzed using the chemiluminescent method with two-step cell stimulation. Indicators of radical-producing activity of neutrophils in patients were compared to those in age-matched healthy people.
RESULTS
The quantitative indicators of radical-producing activity of neutrophils in the paranoid schizophrenia group and in the Alzheimer's disease group correspond to reference intervals of healthy donors, however almost one third of patients with paranoid schizophrenia had an altered shape of the chemiluminescent curve.
CONCLUSION
The neutrophil immune response might be involved in the pathogenesis of paranoid schizophrenia only in some cases.
目的
评估偏执型精神分裂症和阿尔茨海默病中中性粒细胞产生自由基的功能。
材料与方法
该研究纳入了40例偏执型精神分裂症患者和22例阿尔茨海默病患者。为评估中性粒细胞的功能活性，采用两步细胞刺激化学发光法对全血样本进行分析。将患者中性粒细胞产生自由基活性的指标与年龄匹配的健康人进行比较。
结果
偏执型精神分裂症组和阿尔茨海默病组中性粒细胞产生自由基活性的定量指标与健康供体的参考区间相符，但近三分之一的偏执型精神分裂症患者化学发光曲线形状改变。
结论
中性粒细胞免疫反应可能仅在某些情况下参与偏执型精神分裂症的发病机制。
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