Ostroumova T M, Ostroumova O D, Filippova Y A, Parfenov V A
Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.
Russian Medical Academy of Continuing Professional Education, Moscow, Russia.
Zh Nevrol Psikhiatr Im S S Korsakova. 2020;120(4):129-135. doi: 10.17116/jnevro2020120041129.
Restless legs syndrome (RLS) is a sensorimotor disorder characterized by complaints of a strong desire to move legs during periods of rest or inactivity, which is relieved by movement (most pronounced in the evening or at night). Multiple studies have reported drug-induced RLS caused by antipsychotics, antidepressants and antiepileptic medications. Risk factors for drug-induced RLS include older age, gastrointestinal diseases, high medication dose, simultaneous use of ≥2 drugs. The mechanism of drug-induced RLS is most often associated with the effect of medications on various receptors and neurotransmitter systems, in particular, the dopamine system. Drug-induced RLS treatment includes identification and withdrawal of a drug that caused RLS or a decrease in its dosage. Prevention of drug-induced RLS is based on compliance with the principles of rational pharmacotherapy.
不宁腿综合征（RLS）是一种感觉运动障碍，其特征是在休息或不活动期间强烈渴望移动腿部，并通过运动缓解（在晚上或夜间最为明显）。多项研究报告了抗精神病药、抗抑郁药和抗癫痫药引起的药物性RLS。药物性RLS的危险因素包括年龄较大、胃肠道疾病、高药物剂量、同时使用≥2种药物。药物性RLS的机制最常与药物对各种受体和神经递质系统，特别是多巴胺系统的作用有关。药物性RLS的治疗包括识别和停用引起RLS的药物或减少其剂量。药物性RLS的预防基于遵循合理药物治疗原则。
