State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science & Technology, Macau SAR, China.
Department of Pediatrics, Kiang Wu Hospital, Macau SAR, China.
Future Microbiol. 2020 May;15:591-600. doi: 10.2217/fmb-2019-0301. Epub 2020 Jun 3.
Here, we hypothesize that dysbiotic gut microbiota might contribute to the development of Kawasaki disease (KD), a pediatric disease with unknown etiology. This is the second report on gut microbiota composition in KD patients. 16S amplicon sequencing was performed on fecal DNA samples and revealed predominance of bacterial pathogens, such as , , and , in the gut of KD patients, but absent or suppressed after immunoglobulin/antibiotics therapy. In addition, beneficial bacteria propagated after the therapy. We conclude that prevalence of Fusobacteria, and might contribute to KD pathogenesis.
在这里，我们假设肠道菌群失调可能导致川崎病（KD）的发生，这种儿科疾病的病因尚不清楚。这是关于川崎病患者肠道微生物组组成的第二份报告。对粪便 DNA 样本进行 16S 扩增子测序，结果显示川崎病患者肠道中以细菌病原体为主，如 、 、 、 等，但在免疫球蛋白/抗生素治疗后消失或受到抑制。此外，治疗后有益菌大量繁殖。我们的结论是，梭杆菌属、 、 和 的流行可能与 KD 的发病机制有关。
