痢疾志贺氏菌I型肠毒素对小肠糖和氨基酸转运的抑制作用。
Inhibition of small-intestinal sugar and amino acid transport by the enterotoxin of Shigella dysenteriae I.
作者信息
Binder H J, Whiting D S
出版信息
Infect Immun. 1977 May;16(2):510-2. doi: 10.1128/iai.16.2.510-512.1977.
Abstract
The enterotoxin of Shigella dysenteriae I produces fluid and electrolyte secretion in the rabbit ileum. These present studies were designed to evaluate nonelectrolyte transport in rabbit ileal mucosa exposed to Shigella enterotoxin. Both 10 mM galactose and 5 mM L-alanine absorptions were significantly impaired in enterotoxin-exposed ileal mucosa compared with control mucosa. L-Alanine influx was not imparied in two other secretory processes: that induced by cholera enterotoxin and hyperosmolarity. These studies provide evidence that both surgar and amino acid absorptions are diminished in the small intestine by the enterotoxin of S. dysenteriae I.
摘要
痢疾志贺菌I型的肠毒素可使兔回肠分泌液体和电解质。目前这些研究旨在评估暴露于志贺菌肠毒素的兔回肠黏膜中的非电解质转运。与对照黏膜相比，暴露于肠毒素的回肠黏膜中10 mM半乳糖和5 mM L-丙氨酸的吸收均显著受损。在由霍乱肠毒素和高渗引起的另外两种分泌过程中，L-丙氨酸内流并未受损。这些研究提供了证据，表明痢疾志贺菌I型的肠毒素会使小肠中的糖类和氨基酸吸收减少。
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