Ministério da Saúde, Brasília, DF, Brasil.
Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.
Arq Bras Cardiol. 2020 Apr;114(4):692-698. doi: 10.36660/abc.20190176. Epub 2020 May 29.
Background Coronary failure is the leading cause of death worldwide and identifying patients at higher risk for coronary artery disease (CAD) is a challenge. Objectives To test the biomarkers interleukin 18 (IL-18) and thrombus precursor protein (TpP), involved in atherogenesis, to aid in the early assessment of CAD. Methods This was a cross-sectional cohort of 119 patients, stratified into three groups: Group I - acute coronary syndrome (39); Group II - chronic CAD (40) and Group III - control, without coronary lesion, but who might have risk factors for CAD (40). Statistical analysis was performed using the statistical program SPSS (Statistical Package for the Social Sciences) for Windows ,version 17.0 of 2008. The significance level was set at 0.05 or 5% (p <0.05), with a 95% confidence interval. Chi-square test (χ2), Analysis of variance (ANOVA), and Tukey's test were used. Results The mean age was 60.36 ± 9.64 years; there was a prevalence of females in Group III (65.0% p = 0.002), but without statistical significance for the means of IL-18 and TpP. The means of IL-18 and TpP were increased in Group I when compared to the other groups; IL-18 = 1325.44 ± 1860.13 ng/dL, p = 0.002; TpP = 35.86 ± 28.36 µg / mL, p <0.001). When compared two-by-two, it was observed that Group I had higher mean IL-18 and TpP values than Group II (IL-18 = 353.81 ± 273.65 ng / dL; TpP = 25.66 ± 12, 17 µg / mL) and Group III (IL-18 = 633.25 ± 993.93 ng / dL; TpP = 18.00 ± 8.45 µg / mL). Conclusion There was an increase in these biomarkers in acute CAD, suggesting a relationship with the atherosclerotic plaque instability process, but not with the chronic phase. (Arq Bras Cardiol. 2020; 114(4):692-698).
冠状动脉衰竭是全球范围内导致死亡的主要原因，识别患有冠状动脉疾病（CAD）风险较高的患者是一项挑战。目的：检测参与动脉粥样硬化形成的白细胞介素 18（IL-18）和血栓前体蛋白（TpP）等生物标志物，以帮助早期评估 CAD。方法：这是一项横断面队列研究，共纳入 119 例患者，分为三组：I 组 - 急性冠状动脉综合征（39 例）；II 组 - 慢性 CAD（40 例）和 III 组 - 对照组，无冠状动脉病变，但可能存在 CAD 危险因素（40 例）。统计分析采用 Windows 版 SPSS（社会科学统计软件包）统计程序版本 17.0 进行。显著水平设定为 0.05 或 5%（p<0.05），置信区间为 95%。使用卡方检验（χ2）、方差分析（ANOVA）和 Tukey 检验。结果：平均年龄为 60.36±9.64 岁；III 组女性患病率较高（65.0%，p=0.002），但白细胞介素 18 和 TpP 的平均值无统计学意义。与其他两组相比，I 组的白细胞介素 18 和 TpP 平均值升高；白细胞介素 18=1325.44±1860.13ng/dL，p=0.002；TpP=35.86±28.36μg/mL，p<0.001）。两两比较时，观察到 I 组的白细胞介素 18 和 TpP 值高于 II 组（白细胞介素 18=353.81±273.65ng/dL；TpP=25.66±12,17μg/mL）和 III 组（白细胞介素 18=633.25±993.93ng/dL；TpP=18.00±8.45μg/mL）。结论：急性 CAD 中这些生物标志物增加，提示与动脉粥样硬化斑块不稳定过程有关，但与慢性期无关。（Arq Bras Cardiol. 2020; 114(4):692-698）。
