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剥脱性激光换肤

Ablative Laser Resurfacing

作者信息

Verma Neil, Yumeen Sara, Raggio Blake S.

机构信息

University of Toronto, Toronto, ON

Warren Alpert Medical School of Brown University

Abstract

In the simplest sense, ablative laser skin resurfacing describes the process of removing the epidermal and superficial dermal layers of the skin to reduce cutaneous signs of photoaging. Other indications for ablative laser skin resurfacing include scarring, actinic keratoses, seborrheic keratoses, and facial wrinkles. The use of lasers for ablating and resurfacing is based upon the concept of selective thermolysis of the epidermal and dermal layers of the skin through the delivery of light energy. Light energy emitted by the laser is absorbed by the skin's two main chromophores, melanin, and water, which then emit thermal energy, destroying the surrounding tissue.  Laser resurfacing technology has benefited from a number of breakthroughs in the last few decades, with the use of continuous-wave carbon dioxide (CO2) lasers beginning in the 1980s. The implementation of pulsed delivery of CO2 laser energy and the subsequent development of the erbium-doped yttrium aluminum garnet (Er:YAG) laser, which gained popularity in the late 1990s, further improved the precision and depth of cutaneous ablation and reduced the incidence of adverse effects. Additional refinement in skin resurfacing occurred in the early 2000s with the advent of fractional lasers, which are lasers that use narrow, microscopic columns of light to treat a specific portion of the skin. This less destructive modality further reduced the incidence of adverse events and increased the degree of therapeutic control while still seemingly providing comparable results to non-fractional modalities. Depending on the indication, the technician may choose to employ a specific ablative laser (e.g., CO2 or Er:YAG) with a multitude of different settings, including fractional versus non-fractional, to achieve the desired result and, more importantly, minimize laser-associated complications such as scarring, persistent erythema, and dyspigmentation. All in all, ablative lasers represent a safe and effective tool for skin resurfacing, some nuances of which will be discussed herein.

摘要

从最简单的意义上讲,剥脱性激光皮肤重建术描述的是去除皮肤表皮层和真皮浅层以减少光老化皮肤迹象的过程。剥脱性激光皮肤重建术的其他适应症包括瘢痕、光化性角化病、脂溢性角化病和面部皱纹。使用激光进行消融和重建是基于通过传递光能对皮肤表皮层和真皮层进行选择性热解的概念。激光发射的光能被皮肤的两种主要发色团——黑色素和水吸收,然后它们释放热能,破坏周围组织。在过去几十年中,激光重建技术受益于多项突破,20世纪80年代开始使用连续波二氧化碳(CO2)激光。20世纪90年代末流行起来的CO2激光能量脉冲输送的实施以及随后掺铒钇铝石榴石(Er:YAG)激光的发展,进一步提高了皮肤消融的精度和深度,并降低了不良反应的发生率。21世纪初,随着分数激光的出现,皮肤重建技术有了进一步改进,分数激光是一种使用狭窄的微小光柱来治疗皮肤特定部位的激光。这种破坏性较小的方式进一步降低了不良事件的发生率,并提高了治疗控制程度,同时似乎仍能提供与非分数方式相当的效果。根据适应症,技术人员可能会选择使用具有多种不同设置(包括分数与非分数)的特定剥脱性激光(如CO2或Er:YAG),以达到预期效果,更重要的是,将激光相关并发症(如瘢痕形成、持续性红斑和色素沉着异常)降至最低。总而言之,剥脱性激光是一种安全有效的皮肤重建工具,本文将讨论其中的一些细微差别。

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