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Promising effects of tocilizumab in COVID-19: A non-controlled, prospective clinical trial.托珠单抗治疗 COVID-19 的疗效：一项非对照、前瞻性临床试验。
Int Immunopharmacol. 2020 Nov;88:106869. doi: 10.1016/j.intimp.2020.106869. Epub 2020 Aug 4.

本文引用的文献

1
Use of subcutaneous tocilizumab in patients with COVID-19 pneumonia.皮下注射托珠单抗在新冠肺炎肺炎患者中的应用。
J Med Virol. 2021 Jan;93(1):32-34. doi: 10.1002/jmv.26016. Epub 2020 Sep 30.
2
Tocilizumab treatment in COVID-19: A single center experience.托珠单抗治疗 COVID-19：单中心经验。
J Med Virol. 2020 Jul;92(7):814-818. doi: 10.1002/jmv.25801. Epub 2020 Apr 15.
3
COVID-19: consider cytokine storm syndromes and immunosuppression.2019冠状病毒病：考虑细胞因子风暴综合征和免疫抑制。
Lancet. 2020 Mar 28;395(10229):1033-1034. doi: 10.1016/S0140-6736(20)30628-0. Epub 2020 Mar 16.
4
Efficacy and safety of subcutaneous tocilizumab versus intravenous tocilizumab in combination with traditional DMARDs in patients with RA at week 97 (SUMMACTA).皮下注射托珠单抗与静脉注射托珠单抗联合传统改善病情抗风湿药治疗类风湿关节炎患者97周时的疗效和安全性（SUMMACTA研究）
Ann Rheum Dis. 2016 Jan;75(1):68-74. doi: 10.1136/annrheumdis-2015-207281. Epub 2015 Jun 8.
5
Drug absorption, distribution, metabolism and excretion considerations in critically ill adults.成人危重症患者的药物吸收、分布、代谢和排泄考虑因素。
Expert Opin Drug Metab Toxicol. 2013 Sep;9(9):1067-84. doi: 10.1517/17425255.2013.799137. Epub 2013 May 17.
6
Pharmacokinetics and pharmacodynamics of tocilizumab, a humanized anti-interleukin-6 receptor monoclonal antibody, following single-dose administration by subcutaneous and intravenous routes to healthy subjects.托珠单抗（一种人源化抗白细胞介素-6受体单克隆抗体）经皮下和静脉途径单剂量给药于健康受试者后的药代动力学和药效学。
Int J Clin Pharmacol Ther. 2013 Jun;51(6):443-55. doi: 10.5414/CP201819.

Tocilizumab administration in patients with SARS-CoV-2 infection: Subcutaneous injection vs intravenous infusion.

作者信息

Shabani Minoosh, Shokouhi Shervin, Moradi Omid, Saffaei Ali, Sahraei Zahra

机构信息

Department of Infectious Diseases and Tropical Medicine, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Infectious Diseases and Tropical Medicine Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

出版信息

J Med Virol. 2021 Jan;93(1):69-70. doi: 10.1002/jmv.26124. Epub 2020 Jun 19.

DOI:10.1002/jmv.26124
PMID:32492210
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7300729/
Abstract
摘要