《人鼠之间》：烟酰胺腺嘌呤二核苷酸（NAD）提升剂——为线粒体肌病患者带来希望。
Of Mice and Men: NAD Boosting with Niacin Provides Hope for Mitochondrial Myopathy Patients.
机构信息
Department of Anesthesiology and Experimental Therapeutics, Kogod Center on Aging and Co-director of Mayo Clinic Mitochondrial Research Center, Mayo Clinic, Rochester, MN 55905, USA.
出版信息
Cell Metab. 2020 Jun 2;31(6):1041-1043. doi: 10.1016/j.cmet.2020.05.013.
PMID:32492387
Abstract
In this issue of Cell Metabolism, Pirinen et al. (2020) show that disruption in NAD homeostasis is a key component of the pathogenesis of mitochondrial myopathy in humans that can be targeted by the administration of the NAD precursor niacin, identifying NAD boosting as a potential treatment for this devastating disease.
摘要
在本期《细胞代谢》中，Pirinen 等人（2020 年）表明，NAD 动态平衡的破坏是人类线粒体肌病发病机制的一个关键组成部分，通过给予 NAD 前体烟酸可以靶向治疗该疾病，这也确定了 NAD 提升作为治疗这种毁灭性疾病的一种潜在疗法。
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