ISG15 如何对抗病毒感染。
How ISG15 combats viral infection.
机构信息
Department of Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, GA, United States.
Viral Special Pathogens Branch, Division of High Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, GA, United States.
出版信息
Virus Res. 2020 Sep;286:198036. doi: 10.1016/j.virusres.2020.198036. Epub 2020 May 31.
Abstract
Interferon (IFN)-stimulated gene product 15 (ISG15) is a ubiquitin-like protein critical for the control of microbial infections. ISG15 appears to serve a wide variety of functions, which regulate multiple cellular responses contributing to the development of an antiviral state. ISG15 is a versatile molecule directly modulating both host and virus protein function which regulate many signaling pathways, including its own synthesis. Here we review the various roles ISG15 plays in the antiviral immune response, and examine the mechanisms by which viruses attempt to mitigate or exploit ISG15 activity.
摘要
干扰素刺激基因产物 15（ISG15）是一种泛素样蛋白，对控制微生物感染至关重要。ISG15 似乎具有多种功能，可调节多种细胞反应，有助于形成抗病毒状态。ISG15 是一种多功能分子，可直接调节宿主和病毒蛋白的功能，从而调节许多信号通路，包括其自身的合成。本文综述了 ISG15 在抗病毒免疫反应中的各种作用，并探讨了病毒试图减轻或利用 ISG15 活性的机制。
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