Tsourdi Elena, Nees Josef A, Hofbauer Lorenz C
Bereich Endokrinologie/Diabetes/Metabolische Knochenerkrankungen, Medizinische Klinik III & UniversitätsCentrum für Gesundes Altern (UCGA), Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden.
Dtsch Med Wochenschr. 2020 Jun;145(11):728-732. doi: 10.1055/a-1036-2701. Epub 2020 Jun 3.
The global prevalence of osteoporotic fractures and the socioeconomic burden is increasing with aging of the population. Frailty, sarcopenia, malnutrition and a propensity to falls are contributing to osteoporotic fractures in old age with an estimated 750 000 fragility fractures per year in Germany. Despite this increasing number of fractures, osteoporosis remains underdiagnosed and undertreated in the geriatric population. In order to estimate fracture risk in elderly patients, it is important to combine bone mineral density measurement by dual-energy X-ray absorptiometry (DXA) with a problem-oriented geriatric assessment. This includes evaluation of muscle strength, walking speed, nutritional status, risk of falls, as well as cognitive function. Since age per se is the dominant fracture risk factor in women over 70 and men over 80, it is possible to omit DXA measurement in this age group, especially after an incident fragility fracture. The cornerstones of an effective fall and fracture prevention include a targeted training of strength, endurance, coordination and balance in addition to a healthy and active lifestyle. Because of the high prevalence of calcium and/or vitamin D deficiency in old age, close monitoring and appropriate substitution are essential in the management of osteoporosis in the elderly. Anti-osteoporotic drugs are effective and well tolerated in the geriatric population and should be initiated to prevent fractures in high risk cohorts and for secondary prevention. Recently, coordinator-based fracture liaison services have been shown to effectively reduce fracture risk in the high risk geriatric population.
随着人口老龄化,骨质疏松性骨折的全球患病率和社会经济负担正在增加。身体虚弱、肌肉减少症、营养不良和跌倒倾向导致老年人发生骨质疏松性骨折,德国每年估计有75万例脆性骨折。尽管骨折数量不断增加,但在老年人群中,骨质疏松症仍未得到充分诊断和治疗。为了评估老年患者的骨折风险,将双能X线吸收法(DXA)测量骨密度与以问题为导向的老年评估相结合很重要。这包括评估肌肉力量、步行速度、营养状况、跌倒风险以及认知功能。由于年龄本身是70岁以上女性和80岁以上男性的主要骨折危险因素,在这个年龄组中可以省略DXA测量,尤其是在发生脆性骨折之后。有效的预防跌倒和骨折的基石包括除了健康积极的生活方式外,还要有针对性地进行力量、耐力、协调性和平衡训练。由于老年人钙和/或维生素D缺乏的患病率很高,在老年骨质疏松症的管理中,密切监测和适当补充至关重要。抗骨质疏松药物在老年人群中有效且耐受性良好,应在高危人群中启动以预防骨折并进行二级预防。最近,基于协调员的骨折联络服务已被证明能有效降低高危老年人群的骨折风险。