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[老年人群中的骨质疏松症]

[Osteoporosis in the geriatric population].

作者信息

Tsourdi Elena, Nees Josef A, Hofbauer Lorenz C

机构信息

Bereich Endokrinologie/Diabetes/Metabolische Knochenerkrankungen, Medizinische Klinik III & UniversitätsCentrum für Gesundes Altern (UCGA), Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden.

出版信息

Dtsch Med Wochenschr. 2020 Jun;145(11):728-732. doi: 10.1055/a-1036-2701. Epub 2020 Jun 3.

DOI:10.1055/a-1036-2701
PMID:32492741
Abstract

The global prevalence of osteoporotic fractures and the socioeconomic burden is increasing with aging of the population. Frailty, sarcopenia, malnutrition and a propensity to falls are contributing to osteoporotic fractures in old age with an estimated 750 000 fragility fractures per year in Germany. Despite this increasing number of fractures, osteoporosis remains underdiagnosed and undertreated in the geriatric population. In order to estimate fracture risk in elderly patients, it is important to combine bone mineral density measurement by dual-energy X-ray absorptiometry (DXA) with a problem-oriented geriatric assessment. This includes evaluation of muscle strength, walking speed, nutritional status, risk of falls, as well as cognitive function. Since age per se is the dominant fracture risk factor in women over 70 and men over 80, it is possible to omit DXA measurement in this age group, especially after an incident fragility fracture. The cornerstones of an effective fall and fracture prevention include a targeted training of strength, endurance, coordination and balance in addition to a healthy and active lifestyle. Because of the high prevalence of calcium and/or vitamin D deficiency in old age, close monitoring and appropriate substitution are essential in the management of osteoporosis in the elderly. Anti-osteoporotic drugs are effective and well tolerated in the geriatric population and should be initiated to prevent fractures in high risk cohorts and for secondary prevention. Recently, coordinator-based fracture liaison services have been shown to effectively reduce fracture risk in the high risk geriatric population.

摘要

随着人口老龄化,骨质疏松性骨折的全球患病率和社会经济负担正在增加。身体虚弱、肌肉减少症、营养不良和跌倒倾向导致老年人发生骨质疏松性骨折,德国每年估计有75万例脆性骨折。尽管骨折数量不断增加,但在老年人群中,骨质疏松症仍未得到充分诊断和治疗。为了评估老年患者的骨折风险,将双能X线吸收法(DXA)测量骨密度与以问题为导向的老年评估相结合很重要。这包括评估肌肉力量、步行速度、营养状况、跌倒风险以及认知功能。由于年龄本身是70岁以上女性和80岁以上男性的主要骨折危险因素,在这个年龄组中可以省略DXA测量,尤其是在发生脆性骨折之后。有效的预防跌倒和骨折的基石包括除了健康积极的生活方式外,还要有针对性地进行力量、耐力、协调性和平衡训练。由于老年人钙和/或维生素D缺乏的患病率很高,在老年骨质疏松症的管理中,密切监测和适当补充至关重要。抗骨质疏松药物在老年人群中有效且耐受性良好,应在高危人群中启动以预防骨折并进行二级预防。最近,基于协调员的骨折联络服务已被证明能有效降低高危老年人群的骨折风险。

相似文献

1
[Osteoporosis in the geriatric population].[老年人群中的骨质疏松症]
Dtsch Med Wochenschr. 2020 Jun;145(11):728-732. doi: 10.1055/a-1036-2701. Epub 2020 Jun 3.
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Investigation and analysis of osteoporosis, falls, and fragility fractures in elderly people in the Beijing area: a study on the bone health status of elderly people ≥ 80 years old with life self-care.北京地区老年人骨质疏松、跌倒和脆性骨折的调查分析:≥80 岁生活自理老年人骨健康状况的研究。
Arch Osteoporos. 2017 Dec 6;12(1):108. doi: 10.1007/s11657-017-0408-2.
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Internist (Berl). 2014 Jul;55(7):755-61. doi: 10.1007/s00108-014-3468-z.
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Injury. 2017 Dec;48 Suppl 7:S27-S33. doi: 10.1016/j.injury.2017.08.035. Epub 2017 Aug 26.
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Does Combined Osteopenia/Osteoporosis and Sarcopenia Confer Greater Risk of Falls and Fracture Than Either Condition Alone in Older Men? The Concord Health and Ageing in Men Project.老年男性骨质疏松/骨量减少症合并肌肉减少症与单一疾病相比是否会增加跌倒和骨折的风险?康科德健康与男性衰老研究。
J Gerontol A Biol Sci Med Sci. 2019 May 16;74(6):827-834. doi: 10.1093/gerona/gly162.
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Hip fractures are preventable: a proposal for osteoporosis screening and fall prevention in older people.髋部骨折是可预防的:一项针对老年人骨质疏松症筛查和跌倒预防的提议。
Hong Kong Med J. 2020 Jun;26(3):227-235. doi: 10.12809/hkmj198337.
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Rush Fracture Liaison Service for capturing "missed opportunities" to treat osteoporosis in patients with fragility fractures.脆性骨折联络服务,以捕捉治疗脆性骨折患者骨质疏松症的“错失机会”。
Osteoporos Int. 2018 Aug;29(8):1861-1874. doi: 10.1007/s00198-018-4559-9. Epub 2018 Jun 4.
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Secondary prevention of minor trauma fractures: the effects of a tailored intervention-an observational study.轻微创伤性骨折的二级预防:定制干预的效果——一项观察性研究。
Arch Osteoporos. 2019 Mar 29;14(1):44. doi: 10.1007/s11657-019-0595-0.

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