Gori Eleonora, Pierini Alessio, Lippi Ilaria, Meucci Valentina, Perondi Francesca, Marchetti Veronica
Department of Veterinary Sciences, University of Pisa, Via Livornese Lato Monte, 56121 Pisa, Italy.
Vet Sci. 2020 Jun 1;7(2):72. doi: 10.3390/vetsci7020072.
Symmetric dimethylarginine (SDMA) is considered an important biomarker of kidney dysfunction. The aims of the study were to evaluate SDMA in dogs with acute pancreatitis (AP) and its relationship with the presence of kidney injury and mortality. A cohort study including fifty-four dogs with AP diagnosed using compatible clinical and laboratory parameters, abnormal SNAP cPL and compatible abdominal ultrasound within 48 h from admission, was conducted. Dogs with history of renal and/or urinary diseases were excluded, along with dogs exposed to nephrotoxic drugs. Serum urea and creatinine and urinary output (UO) were recorded. Acute kidney injury (AKI) was diagnosed and graded using International Renal Interest Society (IRIS) guidelines. SDMA was measured using high performance liquid chromatography. Fifty-four dogs were included and divided in non-AKI ( = 37) and AKI dogs ( = 17). Twenty-three dogs (14 non-AKI) had SDMA > 15 μg/dL. Median SDMA was higher in AKI dogs than non-AKI dogs (25.7 vs. 13.93 μg/dL; = 0.03). Dogs with normal creatinine (AP and AKI 1 dogs) had SDMA above reference range in 38% and 33% of cases, respectively. In AKI dogs, SDMA and creatinine were positively correlated ( = 0.006 = 0.7). SDMA was not significantly different between survivors and non-survivors. Although further studies are warranted, SDMA may be a useful tool in canine AP, as a high SDMA may be related to subclinical kidney impairment.
对称二甲基精氨酸（SDMA）被认为是肾功能不全的重要生物标志物。本研究的目的是评估急性胰腺炎（AP）犬的SDMA及其与肾损伤和死亡率的关系。进行了一项队列研究，纳入了54只根据临床和实验室参数确诊为AP的犬，这些犬在入院后48小时内SNAP cPL异常且腹部超声检查结果相符。排除有肾脏和/或泌尿系统疾病史的犬，以及接触过肾毒性药物的犬。记录血清尿素、肌酐和尿量（UO）。根据国际肾脏兴趣协会（IRIS）指南诊断和分级急性肾损伤（AKI）。使用高效液相色谱法测量SDMA。共纳入54只犬，分为非AKI犬（n = 37）和AKI犬（n = 17）。23只犬（14只非AKI犬）的SDMA>15μg/dL。AKI犬的SDMA中位数高于非AKI犬（25.7 vs. 13.93μg/dL；P = 0.03）。肌酐正常的犬（AP和AKI 1级犬）中，分别有38%和33%的病例SDMA高于参考范围。在AKI犬中，SDMA与肌酐呈正相关（P = 0.006；r = 0.7）。幸存者和非幸存者之间的SDMA无显著差异。尽管有必要进行进一步研究，但SDMA可能是犬AP中的一个有用工具，因为高SDMA可能与亚临床肾损伤有关。
