Evolutionary Biology Centre, Uppsala University, 75236 Uppsala, Sweden.
Institute of Environmental Medicine, Karolinska Institute, 17177 Stockholm, Sweden.
Int J Mol Sci. 2020 Jun 1;21(11):3978. doi: 10.3390/ijms21113978.
Ubiquitous exposure to endocrine-disrupting chemicals (EDCs) has caused serious concerns about the ability of these chemicals to affect neurodevelopment, among others. Since endocrine disruption (ED)-induced developmental neurotoxicity (DNT) is hardly covered by the chemical testing tools that are currently in regulatory use, the Horizon 2020 research and innovation action ENDpoiNTs has been launched to fill the scientific and methodological gaps related to the assessment of this type of chemical toxicity. The ENDpoiNTs project will generate new knowledge about ED-induced DNT and aims to develop and improve in vitro, in vivo, and in silico models pertaining to ED-linked DNT outcomes for chemical testing. This will be achieved by establishing correlative and causal links between known and novel neurodevelopmental endpoints and endocrine pathways through integration of molecular, cellular, and organismal data from in vitro and in vivo models. Based on this knowledge, the project aims to provide adverse outcome pathways (AOPs) for ED-induced DNT and to develop and integrate new testing tools with high relevance for human health into European and international regulatory frameworks.
无处不在的内分泌干扰化学物质（EDCs）的暴露引起了人们对这些化学物质影响神经发育能力的严重关注。由于内分泌干扰（ED）诱导的发育神经毒性（DNT）几乎没有涵盖目前在监管中使用的化学测试工具，因此启动了 2020 年地平线研究和创新行动 ENDpoiNTs，以填补与评估这种类型的化学毒性相关的科学和方法学空白。ENDpoiNTs 项目将产生关于 ED 诱导的 DNT 的新知识，并旨在开发和改进与 ED 相关的 DNT 结果的体外、体内和计算模型，用于化学测试。这将通过整合体外和体内模型的分子、细胞和机体数据，在已知和新型神经发育终点和内分泌途径之间建立相关和因果联系来实现。基于这些知识，该项目旨在为 ED 诱导的 DNT 提供不良结局途径（AOP），并开发和整合具有高度相关性的新的测试工具，纳入欧洲和国际监管框架。
