多发性硬化症伴排尿功能障碍患者的生活质量：一项横断面研究。
Quality of life among patients with multiple sclerosis and voiding dysfunction: a cross-sectional study.
机构信息
Isfahan neurosciences Research center, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Adult Health Nursing, Faculty of Nursing and Midwifery, Isfahan University of Medical Sciences, Isfahan, Iran.
出版信息
BMC Urol. 2020 Jun 3;20(1):62. doi: 10.1186/s12894-020-00590-w.
BACKGROUND
Evaluating the usefulness of treatment requires a direct measurement of the health-related quality of life (QOL). Therefore, this study was carried out aiming to determine the QOL of patients with MS and voiding dysfunction.
METHODS
This cross-sectional study was carried out using multi-stage random cluster sampling method on 602 patients with MS in Isfahan, Iran. All data were collected through interviews using standard questionnaires including International Prostate Symptom Score (IPSS), and the Multiple Sclerosis Quality of Life-54 (MSQOL-54). Data were analyzed using descriptive and inferential statistical tests.
RESULTS
The prevalence rate of mixed, irritative, and obstructive urinary symptoms was 52.2, 25.5, and 6.5%, respectively. The mixed symptom had the highest prevalence among men and women with rates of 56.5 and 51.1%, respectively. The prevalence of irritative and obstructive symptoms was, respectively, higher and statistically significant among women alone and men alone (P < 0.05). The prevalence of irritative symptoms was higher among patients with MS, EDSS score ≤ 3, disease duration of less than 5 years, and with clinically isolated syndrome. In addition, the prevalence of mixed symptoms was higher among patients with MS of over 30 years of age with a Pre-high school degree, severe disability, disease duration of over 10 years, and progressive MS; the difference was statistically significant (P < 0.05). There was a difference in the combined dimensions of physical and mental health of QOL between the two groups with and without urinary symptoms (P < 0.05). Logistic regression analysis revealed that there was a higher probability of a urinary problems among patients with MS and high age [3.273 (1.083-9.860); P = 0.035].
CONCLUSIONS
Mixed urinary symptoms are highly prevalent among MS patients and affect QOL dimensions. In order to improve QOL, more attention and focus should be paid to urinary problems in MS patients.
背景
评估治疗的效果需要直接测量与健康相关的生活质量（QOL）。因此，本研究旨在确定患有 MS 并伴有排尿功能障碍患者的 QOL。
方法
本横断面研究采用多阶段随机聚类抽样方法，对伊朗伊斯法罕的 602 名 MS 患者进行研究。所有数据均通过使用包括国际前列腺症状评分（IPSS）和多发性硬化生活质量-54 问卷（MSQOL-54）在内的标准问卷进行访谈收集。采用描述性和推断性统计检验对数据进行分析。
结果
混合性、刺激性和阻塞性尿路症状的患病率分别为 52.2%、25.5%和 6.5%。混合性症状在男性和女性中的患病率最高，分别为 56.5%和 51.1%。刺激性和阻塞性症状在女性和男性中单独存在的患病率更高，且具有统计学意义（P ＜ 0.05）。在 MS 患者中，EDSS 评分≤3、病程小于 5 年、有孤立综合征的患者中，更易出现刺激性症状。此外，在年龄超过 30 岁、中学以下学历、严重残疾、病程超过 10 年、进展型 MS 的 MS 患者中，混合症状的患病率更高，差异具有统计学意义（P ＜ 0.05）。在伴有和不伴有尿路症状的两组患者中，身体和心理健康的综合维度存在差异（P ＜ 0.05）。Logistic 回归分析显示，MS 患者年龄较大（3.273[1.083-9.860]；P ＝ 0.035）时，出现尿路问题的可能性更高。
结论
混合性尿路症状在 MS 患者中患病率较高，且影响 QOL 维度。为了提高 QOL，应更加关注 MS 患者的尿路问题。
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