Sabanagic-Hajric Selma, Suljic Enra, Memic-Serdarevic Amra, Sulejmanpasic Gorana, Mahmutbegovic Nevena
Department of Neurology, Clinical Center University of Sarajevo, Sarajevo, Bosnia and Herzegovina.
Department of Psychiatry, Clinical Center University of Sarajevo, Sarajevo, Bosnia and Herzegovina.
Mater Sociomed. 2022 Mar;34(1):19-24. doi: 10.5455/msm.2022.33.19-24.
Multiple sclerosis (MS) is a chronic disease characterised by a wide range of symptoms and a highly unpredictable prognosis, which can severely affect patient quality of life.
The aim of the study was to evaluate the influence of gender, age and marital status on health-related quality of life (HRQoL) in MS patients.
This study included 100 MS patients treated at the Department of Neurology, Clinical Center University of Sarajevo. Inclusion criteria were an Expanded Disability Status Scale score between 1.0 and 6.5, age between 18 and 65 years, stable disease on enrollment. HRQOL was evaluated by the Multiple Sclerosis Quality of Life-54 questionnaire (MSQoL-54). Mann-Whitney and Kruskal-Wallis test were used for comparisons. Linear regression analyses were performed to evaluate prediction value of gender, age and marital status on both physical and mental HRQOL.
Women had significantly lower QOL scores then men in pain scale (55.00 vs. 76.67; p<0, 05). Younger patients had better physical (54.58 vs. 37.90; p<0.05) and mental health (59.55 vs. 45.90; p<0.05) composite scores. Patients with earlier age of onset scored significantly higher in health perception domain scale (45.00 vs. 32.50, p<0.05). Married patinets scored higher in physical and mental composite scores but with no significant difference except in sexual function (87,51 vs 70, 86, p<0,05) and emotional well being (66,67 vs 33,33; p<0,05) scales. Patient age retined its independent predictivity of physical health composite score (r=0.063).
Aging in MS proved to be important negative factor in predicting physical domains of QOL. Interventions for reducing difficulties caused by physical limitations in older patients, higher level of psychological support for patients with late onset disease and social support for those living alone are important factors in improving HRQOL in MS patients.
多发性硬化症（MS）是一种慢性病，其症状多样，预后极难预测，会严重影响患者的生活质量。
本研究旨在评估性别、年龄和婚姻状况对MS患者健康相关生活质量（HRQoL）的影响。
本研究纳入了萨拉热窝大学临床中心神经科治疗的100例MS患者。纳入标准为扩展残疾状态量表评分在1.0至6.5之间，年龄在18至65岁之间，入组时病情稳定。采用多发性硬化症生活质量-54问卷（MSQoL-54）评估HRQOL。使用曼-惠特尼检验和克鲁斯卡尔-沃利斯检验进行比较。进行线性回归分析以评估性别、年龄和婚姻状况对身体和心理HRQOL的预测价值。
在疼痛量表方面，女性的生活质量得分显著低于男性（55.00对76.67；p<0.05）。年轻患者的身体（54.58对37.90；p<0.05）和心理健康（59.55对45.90；p<0.05）综合得分更高。发病年龄较早的患者在健康感知领域量表中的得分显著更高（45.00对32.50，p<0.05）。已婚患者的身体和心理综合得分更高，但除性功能（87.51对70.86，p<0.05）和情绪健康（66.67对33.33；p<0.05）量表外，差异无统计学意义。患者年龄对身体健康综合得分仍具有独立预测性（r=0.063）。
MS患者的年龄增长被证明是预测生活质量身体方面的重要负面因素。减少老年患者身体限制所带来困难的干预措施、对晚发性疾病患者提供更高水平的心理支持以及对独居患者提供社会支持，是改善MS患者HRQoL的重要因素。
