Tenenbaum Ariel, Mandel Asaf, Dor Talia, Sapir Alon, Sapir-Bodnaro Orly, Hertz Pnina, Wexler Isaiah D
Medical Unit for Adoption and Foster Care, Department of Pediatrics, Hadassah University Medical Center, Mount Scopus Campus, 92140, Jerusalem, IL, Israel.
BMC Pediatr. 2020 Jun 3;20(1):275. doi: 10.1186/s12887-020-02164-z.
Fetal alcohol spectrum disorder (FASD) is a leading cause of neurodevelopmental disorders. Children in foster care or domestically adopted are at greater risk for FASD. The aim of this study was to determine the prevalence or risk for FASD in a selected population of foster and adopted children.
Children between 2 and 12 years who were candidates for adoption in foster care were evaluated for clinical manifestations and historical features of fetal alcohol spectrum disorder based on established criteria for FASD.
Of the 89 children evaluated, 18 had mothers with a confirmed history of alcohol consumption during pregnancy. Two children had fetal alcohol syndrome and one had partial fetal alcohol syndrome. In addition, five had alcohol-related neurodevelopmental disorder, one had alcohol-related birth defects, and a single child had manifestations of both. Of the 71 children in which fetal alcohol exposure could not be confirmed, many had manifestations that would have established a diagnosis of FASD were a history of maternal alcohol consumption obtained.
In a population of high-risk children seen in an adoption clinic, many had manifestations associated with FASD especially where prenatal alcohol exposure was established. The reported prevalence in this study is higher than that reported in our previous study of younger children. This is most likely due to the higher number of children diagnosed with alcohol-related neurodevelopmental disorders that typically manifest at an older age.
胎儿酒精谱系障碍(FASD)是神经发育障碍的主要原因。寄养或国内领养的儿童患FASD的风险更高。本研究的目的是确定选定的寄养和领养儿童群体中FASD的患病率或风险。
根据既定的FASD标准,对2至12岁、有寄养领养可能的儿童进行胎儿酒精谱系障碍的临床表现和病史特征评估。
在评估的89名儿童中,18名儿童的母亲在孕期有饮酒史得到证实。两名儿童患有胎儿酒精综合征,一名患有部分胎儿酒精综合征。此外,五名儿童患有酒精相关神经发育障碍,一名患有酒精相关出生缺陷,一名儿童同时有这两种表现。在71名无法证实有胎儿酒精暴露的儿童中,许多儿童若有母亲饮酒史,其表现足以确诊FASD。
在领养诊所见到的高危儿童群体中,许多儿童有与FASD相关的表现,尤其是在确定有产前酒精暴露的情况下。本研究报告的患病率高于我们之前对年幼儿童的研究报告。这很可能是由于被诊断出患有通常在较大年龄出现的酒精相关神经发育障碍的儿童数量较多。