Department of Obstetrics and Gynecology, CHA Bundang Medical Center, 59 Yatap-ro, Seongnam, 13496, Republic of Korea.
Department of Pediatrics, CHA Bundang Medical Center, 59 Yatap-ro, Seongnam, 13496, Republic of Korea.
BMC Pulm Med. 2020 Jun 3;20(1):157. doi: 10.1186/s12890-020-01196-6.
Obstructive sleep apnoea (OSA) is related with adverse pregnancy outcomes, including preeclampsia. However, there are small studies about treatment of OSA with automatic continuous positive airway pressure (CPAP) in adverse obstetric outcomes.
We introduce a case of 34 year old twin pregnant woman diagnosed with superimposed preeclampsia on chronic hypertension at 28 + 1/7 weeks of gestation. A level III polysomnography showed obstructive sleep apnoea, and automatic CPAP was applied. After the CPAP treatment concomitant with an antihypertensive drugs, both blood pressure and urinary protein concentration were reduced. The pregnancy safely continued for 49 days (to 35 + 1/7 weeks), with stable blood pressure, allowing prolongation of gestation of the foetuses.
This is the first case to report OSA with preeclampsia in a twin pregnancy. Our results suggest that automatic CPAP as an adjunct treatment to antihypertensive drugs may be beneficial in controlling blood pressure in early-onset preeclampsia associated with OSA.
阻塞性睡眠呼吸暂停（OSA）与不良妊娠结局有关，包括子痫前期。然而，关于使用自动持续气道正压通气（CPAP）治疗 OSA 对不良产科结局的影响的研究较少。
我们介绍了一位 34 岁的双胞胎孕妇的病例，她在 28+1/7 周妊娠时被诊断为慢性高血压并发子痫前期。三级多导睡眠图显示阻塞性睡眠呼吸暂停，并应用自动 CPAP。CPAP 治疗联合降压药物后，血压和尿蛋白浓度均降低。妊娠安全继续了 49 天（至 35+1/7 周），血压稳定，延长了胎儿的孕周。
这是首例报告在双胞胎妊娠中并发 OSA 和子痫前期的病例。我们的结果表明，自动 CPAP 作为降压药物的辅助治疗可能有益于控制与 OSA 相关的早发型子痫前期的血压。
