Health Outcomes and Economic Evaluation Research Group, Stockholm Centre for Healthcare Ethics, Department of Learning, Informatics, Management and Ethics, Karolinska Institutet, Tomtebodavägen 18 A, SE-171 77, Stockholm, Sweden.
Equity and Health Policy Research Group, Department of Global Public Health, Karolinska Institutet, Stockholm, Sweden.
Health Qual Life Outcomes. 2020 Jun 3;18(1):164. doi: 10.1186/s12955-020-01366-4.
Psychiatric disorders have a major individual and societal impact. Until now, the association between health-related quality of life and physical disorders has been far more investigated than the association with psychiatric disorders. Patient-reported outcome measures makes it possible to capture the patient perspective to improve treatments and evaluate treatment outcomes. The aim of this study is to measure health-related quality of life with the EQ-5D-Y-5L among patients in child and adolescent psychiatric inpatient care and to test the instrument's psychometric properties in terms of feasibility and construct validity.
Data were collected at the child and adolescent psychiatric inpatient facility in Region Stockholm. A questionnaire including the EQ-5D-Y-5L instrument, the Strengths and Difficulties Questionnaire with an impact supplement and a self-rated health question, was administered for self-completion using paper and pencil, with an interviewer present. The Chi-square test was used to investigate differences in proportion of reported problems in the EQ-5D-Y-5L dimensions and the Mann-Whitney U test was used for differences in mean EQ VAS scores. Feasibility was assessed by investigating proportion of missing and ambiguous answers and Spearman's and Pearson's correlation were used to examine construct validity.
In total 52 adolescents participated in the study and the majority were girls. The most common diagnosis at admission was depressive episode/recurrent depressive disorder. All participants reported problems on at least one dimension. Most problems were reported in the dimension 'feeling worried, sad or unhappy', where 64% reported severe or extreme problems. Mean EQ VAS score was 29.2. Feasibility was supported and construct validity indicated as some of the hypothesised correlations between the EQ-5D-Y-5 L and the Strengths and Difficulties Questionnaire were found, however, for 'doing usual activities' and 'having pain or discomfort' the correlations were weaker than hypothesised.
This is the first study where the newly developed EQ-5D-Y-5L instrument has been used in psychiatric inpatient care for youth. Participants reported problems in all severity levels in most of the EQ-5D-Y-5L dimensions; mean EQ VAS score was considerably low. Feasibility of the EQ-5D-Y-5L was supported, however other psychometric properties need to be further tested in a larger sample.
精神障碍对个人和社会都有重大影响。到目前为止，与健康相关的生活质量与身体障碍的关联比与精神障碍的关联受到了更多的研究。患者报告的结果测量使得从患者角度捕捉治疗效果成为可能，从而改善治疗并评估治疗效果。本研究的目的是使用 EQ-5D-Y-5L 在儿童和青少年精神病住院患者中测量与健康相关的生活质量，并根据可行性和结构有效性测试该工具的心理测量特性。
数据是在斯德哥尔摩地区的儿童和青少年精神病住院机构收集的。使用问卷包括 EQ-5D-Y-5L 工具、带有影响补充的困难问卷和自我报告的健康问题，使用纸笔进行自我完成，有采访者在场。使用卡方检验调查 EQ-5D-Y-5L 维度中报告问题的比例差异，使用曼-惠特尼 U 检验调查 EQ VAS 得分的平均值差异。通过调查缺失和模糊答案的比例评估可行性，使用 Spearman 和 Pearson 相关系数检查结构有效性。
共有 52 名青少年参与了这项研究，其中大多数是女孩。入院时最常见的诊断是抑郁发作/复发性抑郁障碍。所有参与者在至少一个维度上都报告了问题。最常见的问题是在“感到担忧、悲伤或不开心”维度上，64%的人报告了严重或极度的问题。平均 EQ VAS 得分为 29.2。可行性得到支持，结构有效性表明，EQ-5D-Y-5L 与困难问卷之间的一些假设相关性得到了证实，然而，对于“进行日常活动”和“有疼痛或不适”这两个维度，相关性比假设的要弱。
这是第一项在青少年精神病住院治疗中使用新开发的 EQ-5D-Y-5L 工具的研究。参与者在 EQ-5D-Y-5L 的大多数维度上报告了所有严重程度的问题；平均 EQ VAS 得分相当低。EQ-5D-Y-5L 的可行性得到支持，但其他心理测量特性需要在更大的样本中进一步测试。
