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舒他西林细粒剂的临床研究

[Clinical study of sultamicillin fine granules].

作者信息

Okada K, Kawakami K, Takeda E

机构信息

Department of Pediatrics, School of Medicine, Tokushima University.

出版信息

Jpn J Antibiot. 1988 Dec;41(12):1954-8.

PMID:3249368
Abstract

Sultamicillin, a mutual prodrug of a beta-lactam antibiotic and beta-lactamase inhibitor, was administered to 19 child patients with infectious diseases. The patients included 9 boys and 10 girls from 11 months to 13 years old and they were given orally a dosage of 15.4-40.8 mg/kg/day for 3 to 12 days. Clinical efficacies were excellent in 2 cases, good in 13 cases, fair in 3 cases, unknown in 1 case, and the total efficacy rate was 83.3%. Loose stool in 1 case and mild diarrhea in another occurred as side effects of the drug, but no abnormal laboratory test values were found upon the treatment.

摘要

舒他西林是一种β-内酰胺抗生素与β-内酰胺酶抑制剂的复方前体药物,对19例患有传染病的儿童患者进行了给药治疗。这些患者包括9名男孩和10名女孩,年龄在11个月至13岁之间,口服剂量为15.4 - 40.8毫克/千克/天,疗程为3至12天。临床疗效为优2例,良13例,中3例,1例情况不明,总有效率为83.3%。1例出现大便溏稀,另1例出现轻度腹泻,为药物副作用,但治疗期间未发现实验室检查值异常。

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